Body Mass and White Matter Integrity: The Influence of Vascular and Inflammatory Markers

Brianne Magouirk Bettcher, Christine M. Walsh, Christa Watson, Joshua W. Miller, Ralph Green, Nihar Patel, Bruce L. Miller, John Neuhaus, Kristine Yaffe, Joel H. Kramer

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

High adiposity is deleteriously associated with brain health, and may disproportionately affect white matter integrity; however, limited information exists regarding the mechanisms underlying the association between body mass (BMI) and white matter integrity. The present study evaluated whether vascular and inflammatory markers influence the relationship between BMI and white matter in healthy aging. We conducted a cross-sectional evaluation of white matter integrity, BMI, and vascular/inflammatory factors in a cohort of 138 healthy older adults (mean age: 71.3 years). Participants underwent diffusion tensor imaging, provided blood samples, and participated in a health evaluation. Vascular risk factors and vascular/inflammatory blood markers were assessed. The primary outcome measure was fractional anisotropy (FA) of the genu, body, and splenium (corpus callosum); exploratory measures included additional white matter regions, based on significant associations with BMI. Regression analyses indicated that higher BMI was associated with lower FA in the corpus callosum, cingulate, and fornix (p<.001). Vascular and inflammatory factors influenced the association between BMI and FA. Specifically, BMI was independently associated with the genu [β=-.21; B=-.0024; 95% CI, -.0048 to -.0000; p=.05] and cingulate fibers [β=-.39; B=-.0035; 95% CI,-.0056 to -.0015; p<.001], even after controlling for vascular/inflammatory risk factors and blood markers. In contrast, BMI was no longer significantly associated with the fornix and middle/posterior regions of the corpus callosum after controlling for these markers. Results partially support a vascular/inflammatory hypothesis, but also suggest a more complex relationship between BMI and white matter characterized by potentially different neuroanatomic vulnerability.

Original languageEnglish (US)
Article numbere77741
JournalPLoS One
Volume8
Issue number10
DOIs
StatePublished - Oct 16 2013

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blood vessels
Blood Vessels
Anisotropy
Blood
Corpus Callosum
Health
Diffusion tensor imaging
Brain
Aging of materials
blood
risk factors
Diffusion Tensor Imaging
Fibers
Adiposity
adiposity
White Matter
Regression Analysis
Outcome Assessment (Health Care)
image analysis
brain

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Bettcher, B. M., Walsh, C. M., Watson, C., Miller, J. W., Green, R., Patel, N., ... Kramer, J. H. (2013). Body Mass and White Matter Integrity: The Influence of Vascular and Inflammatory Markers. PLoS One, 8(10), [e77741]. https://doi.org/10.1371/journal.pone.0077741

Body Mass and White Matter Integrity : The Influence of Vascular and Inflammatory Markers. / Bettcher, Brianne Magouirk; Walsh, Christine M.; Watson, Christa; Miller, Joshua W.; Green, Ralph; Patel, Nihar; Miller, Bruce L.; Neuhaus, John; Yaffe, Kristine; Kramer, Joel H.

In: PLoS One, Vol. 8, No. 10, e77741, 16.10.2013.

Research output: Contribution to journalArticle

Bettcher, BM, Walsh, CM, Watson, C, Miller, JW, Green, R, Patel, N, Miller, BL, Neuhaus, J, Yaffe, K & Kramer, JH 2013, 'Body Mass and White Matter Integrity: The Influence of Vascular and Inflammatory Markers', PLoS One, vol. 8, no. 10, e77741. https://doi.org/10.1371/journal.pone.0077741
Bettcher, Brianne Magouirk ; Walsh, Christine M. ; Watson, Christa ; Miller, Joshua W. ; Green, Ralph ; Patel, Nihar ; Miller, Bruce L. ; Neuhaus, John ; Yaffe, Kristine ; Kramer, Joel H. / Body Mass and White Matter Integrity : The Influence of Vascular and Inflammatory Markers. In: PLoS One. 2013 ; Vol. 8, No. 10.
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