Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose.

M. P. Brown, Susan M Stover, R. H. Kelly, Thomas B Farver

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalEquine Veterinary Journal
Volume14
Issue number1
StatePublished - Jan 1982

ASJC Scopus subject areas

  • veterinary(all)

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