Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose.

M. P. Brown, Susan M Stover, R. H. Kelly, Thomas B Farver

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.

Original languageEnglish (US)
Pages (from-to)83-85
Number of pages3
JournalEquine Veterinary Journal
Volume14
Issue number1
StatePublished - Jan 1982

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body fluids
Body Fluids
Ampicillin
ampicillin
Horses
horses
dosage
blood serum
synovial fluid
Ascitic Fluid
Synovial Fluid
urine
Serum
Urine
mares
Body Weight
body weight

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose. / Brown, M. P.; Stover, Susan M; Kelly, R. H.; Farver, Thomas B.

In: Equine Veterinary Journal, Vol. 14, No. 1, 01.1982, p. 83-85.

Research output: Contribution to journalArticle

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