Abstract
Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-85 |
| Number of pages | 3 |
| Journal | Equine Veterinary Journal |
| Volume | 14 |
| Issue number | 1 |
| State | Published - Jan 1982 |
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ASJC Scopus subject areas
- veterinary(all)
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Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose. / Brown, M. P.; Stover, Susan M; Kelly, R. H.; Farver, Thomas B.
In: Equine Veterinary Journal, Vol. 14, No. 1, 01.1982, p. 83-85.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose.
AU - Brown, M. P.
AU - Stover, Susan M
AU - Kelly, R. H.
AU - Farver, Thomas B
PY - 1982/1
Y1 - 1982/1
N2 - Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.
AB - Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.
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UR - http://www.scopus.com/inward/citedby.url?scp=0020009244&partnerID=8YFLogxK
M3 - Article
VL - 14
SP - 83
EP - 85
JO - Equine veterinary journal. Supplement
JF - Equine veterinary journal. Supplement
SN - 2042-3306
IS - 1
ER -