Abstract
Six adult mares were given a single dose of ampicillin trihydrate (250 mg/ml) intramuscularly at a dosage of 20 mg/kg body weight. Serum, synovial fluid, peritoneal fluid and urine ampicillin concentrations were measured serially over a 48 h period. The mean peak serum ampicillin concentration was 2.49 micrograms/ml at 6 h. Ampicillin was found in synovial fluid and peritoneal fluid, which obtained mean peak ampicillin concentrations of 1.65 micrograms/ml and 1.81 micrograms/ml at 6 h and 4 h respectively. These concentrations declined in parallel with serum concentrations and were still detectable at 48 h. Urine concentration of ampicillin was relatively high, with a mean peak concentration of 1364.9 micrograms/ml at 4 h.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 83-85 |
| Number of pages | 3 |
| Journal | Equine Veterinary Journal |
| Volume | 14 |
| Issue number | 1 |
| State | Published - Jan 1982 |
ASJC Scopus subject areas
- veterinary(all)
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Brown, M. P., Stover, S. M., Kelly, R. H., & Farver, T. B. (1982). Body fluid concentrations of ampicillin trihydrate in 6 horses after a single intramuscular dose. Equine Veterinary Journal, 14(1), 83-85.