Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Shin J. Lee, Jean Philippe Krieger, Macarena Vergara, Danielle Quinn, Molly McDougle, Alan de Araujo, Rebecca Darling, Benjamin Zollinger, Seth Anderson, Annabeth Pan, Emilie J. Simonnet, Angelica Pignalosa, Myrtha Arnold, Arashdeep Singh, Wolfgang Langhans, Helen E. Raybould, Guillaume de Lartigue

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Lee et al. report that consumption of an obesogenic diet inhibits calorie-induced synthesis and release of the neuropeptide CART from sensory vagal neurons. CART knockdown in these neurons mimics the hallmarks of obesity, weight gain, and overeating. Bypassing the vagus nerve with central CART administration effectively reduces feeding in obese rats.

Original languageEnglish (US)
Pages (from-to)2028-2039.e4
JournalCell Reports
Volume30
Issue number6
DOIs
StatePublished - Feb 11 2020

Keywords

  • cholecystokinin
  • diet-induced obesity
  • food intake
  • ingestion
  • neuropeptide
  • nodose ganglia
  • NTS
  • nucleus tractus solitarii
  • vagal afferent neurons
  • vagus nerve

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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