Abstract
Lee et al. report that consumption of an obesogenic diet inhibits calorie-induced synthesis and release of the neuropeptide CART from sensory vagal neurons. CART knockdown in these neurons mimics the hallmarks of obesity, weight gain, and overeating. Bypassing the vagus nerve with central CART administration effectively reduces feeding in obese rats.
Original language | English (US) |
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Pages (from-to) | 2028-2039.e4 |
Journal | Cell Reports |
Volume | 30 |
Issue number | 6 |
DOIs | |
State | Published - Feb 11 2020 |
Keywords
- cholecystokinin
- diet-induced obesity
- food intake
- ingestion
- neuropeptide
- nodose ganglia
- NTS
- nucleus tractus solitarii
- vagal afferent neurons
- vagus nerve
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)