Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Shin J. Lee; Jean Philippe Krieger; Macarena Vergara; Danielle Quinn; Molly McDougle; Alan de Araujo; Rebecca Darling; Benjamin Zollinger; Seth Anderson; Annabeth Pan; Emilie J. Simonnet; Angelica Pignalosa; Myrtha Arnold; Arashdeep Singh; Wolfgang Langhans; Helen E. Raybould; Guillaume de Lartigue

doi:10.1016/j.celrep.2020.01.045

Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Shin J. Lee, Jean Philippe Krieger, Macarena Vergara, Danielle Quinn, Molly McDougle, Alan de Araujo, Rebecca Darling, Benjamin Zollinger, Seth Anderson, Annabeth Pan, Emilie J. Simonnet, Angelica Pignalosa, Myrtha Arnold, Arashdeep Singh, Wolfgang Langhans, Helen E. Raybould, Guillaume de Lartigue

School of Veterinary Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Lee et al. report that consumption of an obesogenic diet inhibits calorie-induced synthesis and release of the neuropeptide CART from sensory vagal neurons. CART knockdown in these neurons mimics the hallmarks of obesity, weight gain, and overeating. Bypassing the vagus nerve with central CART administration effectively reduces feeding in obese rats.

Original language	English (US)
Pages (from-to)	2028-2039.e4
Journal	Cell Reports
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.celrep.2020.01.045
State	Published - Feb 11 2020

Keywords

cholecystokinin
diet-induced obesity
food intake
ingestion
neuropeptide
nodose ganglia
NTS
nucleus tractus solitarii
vagal afferent neurons
vagus nerve

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.celrep.2020.01.045

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Lee, S. J., Krieger, J. P., Vergara, M., Quinn, D., McDougle, M., de Araujo, A., Darling, R., Zollinger, B., Anderson, S., Pan, A., Simonnet, E. J., Pignalosa, A., Arnold, M., Singh, A., Langhans, W., Raybould, H. E., & de Lartigue, G. (2020). Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. Cell Reports, 30(6), 2028-2039.e4. https://doi.org/10.1016/j.celrep.2020.01.045

Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. / Lee, Shin J.; Krieger, Jean Philippe; Vergara, Macarena; Quinn, Danielle; McDougle, Molly; de Araujo, Alan; Darling, Rebecca; Zollinger, Benjamin; Anderson, Seth; Pan, Annabeth; Simonnet, Emilie J.; Pignalosa, Angelica; Arnold, Myrtha; Singh, Arashdeep; Langhans, Wolfgang; Raybould, Helen E.; de Lartigue, Guillaume.

In: Cell Reports, Vol. 30, No. 6, 11.02.2020, p. 2028-2039.e4.

Research output: Contribution to journal › Article › peer-review

Lee, SJ, Krieger, JP, Vergara, M, Quinn, D, McDougle, M, de Araujo, A, Darling, R, Zollinger, B, Anderson, S, Pan, A, Simonnet, EJ, Pignalosa, A, Arnold, M, Singh, A, Langhans, W, Raybould, HE & de Lartigue, G 2020, 'Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain', Cell Reports, vol. 30, no. 6, pp. 2028-2039.e4. https://doi.org/10.1016/j.celrep.2020.01.045

Lee, Shin J. ; Krieger, Jean Philippe ; Vergara, Macarena ; Quinn, Danielle ; McDougle, Molly ; de Araujo, Alan ; Darling, Rebecca ; Zollinger, Benjamin ; Anderson, Seth ; Pan, Annabeth ; Simonnet, Emilie J. ; Pignalosa, Angelica ; Arnold, Myrtha ; Singh, Arashdeep ; Langhans, Wolfgang ; Raybould, Helen E. ; de Lartigue, Guillaume. / Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain. In: Cell Reports. 2020 ; Vol. 30, No. 6. pp. 2028-2039.e4.

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abstract = "Lee et al. report that consumption of an obesogenic diet inhibits calorie-induced synthesis and release of the neuropeptide CART from sensory vagal neurons. CART knockdown in these neurons mimics the hallmarks of obesity, weight gain, and overeating. Bypassing the vagus nerve with central CART administration effectively reduces feeding in obese rats.",

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Blunted Vagal Cocaine- and Amphetamine-Regulated Transcript Promotes Hyperphagia and Weight Gain

Abstract

Keywords

ASJC Scopus subject areas

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