Bluetongue virus-induced interferon in cattle.

Nigel J Maclachlan, J. Thompson

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Calves were inoculated IV with bluetongue virus (BTV), serotype 10. Titers of interferon (IFN) in serum and BTV in peripheral blood were determined. All inoculated calves produced circulating IFN that persisted for 2 to 4 days. Highest titers of BTV in peripheral blood were present after serum IFN was no longer detected. The persistence of BTV in peripheral blood, as compared with the transient IFN response, indicated that IFN was most important in the initial antiviral response of cattle to BTV infection. Bluetongue virus is probably not a suitable model inducer of circulating IFN in cattle because the profound neutropenia that accompanied BTV infection may predispose cattle to infections with other agents.

Original languageEnglish (US)
Pages (from-to)1238-1241
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume46
Issue number6
StatePublished - Jun 1985
Externally publishedYes

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Bluetongue virus
interferons
Interferons
cattle
Virus Diseases
blood serum
blood
Interferon Inducers
calves
infection
neutropenia
Neutropenia
Serum
Antiviral Agents
serotypes
Infection

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Bluetongue virus-induced interferon in cattle. / Maclachlan, Nigel J; Thompson, J.

In: American Journal of Veterinary Research, Vol. 46, No. 6, 06.1985, p. 1238-1241.

Research output: Contribution to journalArticle

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