Bluetongue virus-induced interferon in cattle.

Nigel J Maclachlan, J. Thompson

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Abstract

Calves were inoculated IV with bluetongue virus (BTV), serotype 10. Titers of interferon (IFN) in serum and BTV in peripheral blood were determined. All inoculated calves produced circulating IFN that persisted for 2 to 4 days. Highest titers of BTV in peripheral blood were present after serum IFN was no longer detected. The persistence of BTV in peripheral blood, as compared with the transient IFN response, indicated that IFN was most important in the initial antiviral response of cattle to BTV infection. Bluetongue virus is probably not a suitable model inducer of circulating IFN in cattle because the profound neutropenia that accompanied BTV infection may predispose cattle to infections with other agents.

Original languageEnglish (US)
Pages (from-to)1238-1241
Number of pages4
JournalAmerican Journal of Veterinary Research
Volume46
Issue number6
StatePublished - Jun 1985
Externally publishedYes

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ASJC Scopus subject areas

  • veterinary(all)

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