Bluetongue virus-induced hydranencephaly in cattle.

Nigel J Maclachlan, Bennie Osburn

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Direct inoculation of bluetongue virus into 125-day bovine fetuses resulted in development of hydranencephaly. The earliest lesions after virus inoculation were a severe necrotizing encephalitis, which was most prominent in the cerebrum, and an associated nonsuppurative meningitis. At birth, the brains of infected fetuses had thin-walled cerebral hemispheres, dilated lateral ventricles, and cerebral cysts. No gross lesions were observed in the brain stem or cerebellum. Two morphologically different lesions were present in the brain of a fetus sacrificed 20 days after virus inoculation. There were discrete foci of hemorrhagic cerebral necrosis that resembled infarcts and widespread microcavitations of the intermediate and subventricular zones. Changes consistent with vascular damage were present in the brains of fetuses sacrificed 12 and 20 days after virus inoculation. Calves with bluetongue virus-induced hydranencephaly would have poor viability, but they would not be expected to have any significance as virus reservoirs.

Original languageEnglish (US)
Pages (from-to)563-573
Number of pages11
JournalVeterinary Pathology
Volume20
Issue number5
StatePublished - Sep 1983
Externally publishedYes

Fingerprint

Hydranencephaly
Bluetongue virus
fetus
Fetus
lesions (animal)
Viruses
viruses
Lateral Ventricles
cattle
Cerebrum
brain
Brain
cerebrum
infarction
meningitis
brain stem
cerebellum
Encephalitis
encephalitis
Meningitis

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Bluetongue virus-induced hydranencephaly in cattle. / Maclachlan, Nigel J; Osburn, Bennie.

In: Veterinary Pathology, Vol. 20, No. 5, 09.1983, p. 563-573.

Research output: Contribution to journalArticle

Maclachlan, Nigel J ; Osburn, Bennie. / Bluetongue virus-induced hydranencephaly in cattle. In: Veterinary Pathology. 1983 ; Vol. 20, No. 5. pp. 563-573.
@article{bda1ed8c21cc41169dc87651a5903f69,
title = "Bluetongue virus-induced hydranencephaly in cattle.",
abstract = "Direct inoculation of bluetongue virus into 125-day bovine fetuses resulted in development of hydranencephaly. The earliest lesions after virus inoculation were a severe necrotizing encephalitis, which was most prominent in the cerebrum, and an associated nonsuppurative meningitis. At birth, the brains of infected fetuses had thin-walled cerebral hemispheres, dilated lateral ventricles, and cerebral cysts. No gross lesions were observed in the brain stem or cerebellum. Two morphologically different lesions were present in the brain of a fetus sacrificed 20 days after virus inoculation. There were discrete foci of hemorrhagic cerebral necrosis that resembled infarcts and widespread microcavitations of the intermediate and subventricular zones. Changes consistent with vascular damage were present in the brains of fetuses sacrificed 12 and 20 days after virus inoculation. Calves with bluetongue virus-induced hydranencephaly would have poor viability, but they would not be expected to have any significance as virus reservoirs.",
author = "Maclachlan, {Nigel J} and Bennie Osburn",
year = "1983",
month = "9",
language = "English (US)",
volume = "20",
pages = "563--573",
journal = "Veterinary Pathology",
issn = "0300-9858",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Bluetongue virus-induced hydranencephaly in cattle.

AU - Maclachlan, Nigel J

AU - Osburn, Bennie

PY - 1983/9

Y1 - 1983/9

N2 - Direct inoculation of bluetongue virus into 125-day bovine fetuses resulted in development of hydranencephaly. The earliest lesions after virus inoculation were a severe necrotizing encephalitis, which was most prominent in the cerebrum, and an associated nonsuppurative meningitis. At birth, the brains of infected fetuses had thin-walled cerebral hemispheres, dilated lateral ventricles, and cerebral cysts. No gross lesions were observed in the brain stem or cerebellum. Two morphologically different lesions were present in the brain of a fetus sacrificed 20 days after virus inoculation. There were discrete foci of hemorrhagic cerebral necrosis that resembled infarcts and widespread microcavitations of the intermediate and subventricular zones. Changes consistent with vascular damage were present in the brains of fetuses sacrificed 12 and 20 days after virus inoculation. Calves with bluetongue virus-induced hydranencephaly would have poor viability, but they would not be expected to have any significance as virus reservoirs.

AB - Direct inoculation of bluetongue virus into 125-day bovine fetuses resulted in development of hydranencephaly. The earliest lesions after virus inoculation were a severe necrotizing encephalitis, which was most prominent in the cerebrum, and an associated nonsuppurative meningitis. At birth, the brains of infected fetuses had thin-walled cerebral hemispheres, dilated lateral ventricles, and cerebral cysts. No gross lesions were observed in the brain stem or cerebellum. Two morphologically different lesions were present in the brain of a fetus sacrificed 20 days after virus inoculation. There were discrete foci of hemorrhagic cerebral necrosis that resembled infarcts and widespread microcavitations of the intermediate and subventricular zones. Changes consistent with vascular damage were present in the brains of fetuses sacrificed 12 and 20 days after virus inoculation. Calves with bluetongue virus-induced hydranencephaly would have poor viability, but they would not be expected to have any significance as virus reservoirs.

UR - http://www.scopus.com/inward/record.url?scp=0020824628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020824628&partnerID=8YFLogxK

M3 - Article

C2 - 6314630

AN - SCOPUS:0020824628

VL - 20

SP - 563

EP - 573

JO - Veterinary Pathology

JF - Veterinary Pathology

SN - 0300-9858

IS - 5

ER -