Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats

E. M. Renkin, V. L. Tucker, H. Wiig, George Kaysen, L. Sibley, M. Decarlo, K. Simanonok, M. Wong

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Abstract

Tracer uptake studies were carried out in adult female Nagase (NA) strain analbuminemic rats [derived from Sprague-Dawley (SD) stock] and in adult female SD controls to determine the extent to which capillary permeability to plasma proteins is altered in the absence of endogenous albumin. Accessory measurements (arterial pressure, central venous pressure, plasma and interstitial fluid protein concentrations and oncotic pressures, plasma volume, and interstitial fluid volume) confirm the report of Joles et al. [Am. J. Physiol. 257 (Renal Fluid Electrolyte Physiol. 26): F23-F28, 1989] that shows elevated plasma volumes, normal interstitial fluid volumes, nearly normal plasma oncotic pressures (due to elevated globulin concentrations), and lower interstitial fluid oncotic pressures. In skin, skeletal muscles, and heart muscle, clearances of exogenous heterologous (bovine) albumin were 20-40% higher in NA than in SD controls. In intestine, albumin clearances were 20-30% lower. In NA rats blood-to-tissue clearances of heterologous (bovine) immunoglobulin G in skin and heart were higher and in the intestine they were lower than in SD controls; however, clearances in skeletal muscles were not elevated. The differences between NA and SD are small compared with the large increases in macromolecular permeabilities reported by others for organs and single microvessels perfused with albumin-free fluids. We conclude that 1) other constituents of NA plasma are capable of maintaining nearly normal capillary permeability to plasma proteins, and 2) the lower interstitial fluid protein concentration and oncotic pressure in NA rats are attributable to the absence of the more permeable albumin, with the interstitial fluid-to-plasma concentration ratio for total protein in NA rats being nearly the same as the ratio for plasma globulins in SD controls.

Original languageEnglish (US)
Pages (from-to)559-566
Number of pages8
JournalJournal of Applied Physiology
Volume74
Issue number2
StatePublished - 1993

Fingerprint

Acetylglucosaminidase
Extracellular Fluid
Albumins
Immunoglobulin G
Pressure
Plasma Volume
Globulins
Capillary Permeability
Intestines
Blood Proteins
Skeletal Muscle
Skin
Proteins
Central Venous Pressure
Microvessels
Electrolytes
Sprague Dawley Rats
Permeability
Myocardium
Arterial Pressure

Keywords

  • capillary permeability
  • interstitial fluid protein concentrations
  • interstitial fluid volume
  • Nagase rats
  • plasma oncotic pressures
  • plasma protein concentrations
  • plasma volume
  • Sprague-Dawley controls

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Renkin, E. M., Tucker, V. L., Wiig, H., Kaysen, G., Sibley, L., Decarlo, M., ... Wong, M. (1993). Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats. Journal of Applied Physiology, 74(2), 559-566.

Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats. / Renkin, E. M.; Tucker, V. L.; Wiig, H.; Kaysen, George; Sibley, L.; Decarlo, M.; Simanonok, K.; Wong, M.

In: Journal of Applied Physiology, Vol. 74, No. 2, 1993, p. 559-566.

Research output: Contribution to journalArticle

Renkin, EM, Tucker, VL, Wiig, H, Kaysen, G, Sibley, L, Decarlo, M, Simanonok, K & Wong, M 1993, 'Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats', Journal of Applied Physiology, vol. 74, no. 2, pp. 559-566.
Renkin, E. M. ; Tucker, V. L. ; Wiig, H. ; Kaysen, George ; Sibley, L. ; Decarlo, M. ; Simanonok, K. ; Wong, M. / Blood-tissue transport of exogenous albumin and immunoglobulin G in genetically analbuminemic rats. In: Journal of Applied Physiology. 1993 ; Vol. 74, No. 2. pp. 559-566.
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