Blood lead levels measured prospectively and risk of spontaneous abortion

Victor H. Borja-Aburto, Irva Hertz-Picciotto, Magdalena Rojas Lopez, Paulina Farias, Camilo Rios, Julia Blanco

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Studies of low to moderate level lead exposures have reported mixed findings regarding the risk of spontaneous abortion, despite lead's abortifacient properties at very high doses. To evaluate the risk of spontaneous abortion from low or moderate lead exposures, a nested case- control study was conducted within a cohort of pregnant women in Mexico City, 1994-1996. During their first trimester, 668 women enrolled, were interviewed, and contributed blood specimens. Pregnancies were followed by home visits or telephone calls. Spontaneous abortions before week 21 (n = 35) were matched with pregnancies that survived beyond week 20 (n = 60) on maternal age, hospital, date of enrollment, and gestational age at enrollment. Mean blood lead levels were 12.03 μg/dL for cases and 10.09 μg/dL for controls (p = 0.02). Odds ratios for spontaneous abortion comparing 5-9, 10-14, and ≥15 μg/dL with the referent category of <5 μg/dL of blood lead were 2.3, 5.4, and 12.2, respectively, demonstrating a significant trend (p = 0.03). After multivariate adjustment, the odds ratio for spontaneous abortion was 1.8 (95% confidence interval = 1.1, 3.1) for every 5 μg/dL increase in blood lead. Low to moderate lead exposures may increase the risk for spontaneous abortion at exposures comparable to US general population levels during the 1970s and to many populations worldwide today; these are far lower than exposures encountered in some occupations.

Original languageEnglish (US)
Pages (from-to)590-597
Number of pages8
JournalAmerican Journal of Epidemiology
Volume150
Issue number6
StatePublished - Sep 15 1999
Externally publishedYes

Fingerprint

Spontaneous Abortion
Odds Ratio
Abortifacient Agents
Pregnancy
House Calls
Maternal Age
First Pregnancy Trimester
Mexico
Lead
Occupations
Telephone
Population
Gestational Age
Case-Control Studies
Pregnant Women
Confidence Intervals

Keywords

  • Abortion
  • Blood
  • Lead
  • Lead poisoning
  • Pregnancy outcome

ASJC Scopus subject areas

  • Epidemiology

Cite this

Borja-Aburto, V. H., Hertz-Picciotto, I., Lopez, M. R., Farias, P., Rios, C., & Blanco, J. (1999). Blood lead levels measured prospectively and risk of spontaneous abortion. American Journal of Epidemiology, 150(6), 590-597.

Blood lead levels measured prospectively and risk of spontaneous abortion. / Borja-Aburto, Victor H.; Hertz-Picciotto, Irva; Lopez, Magdalena Rojas; Farias, Paulina; Rios, Camilo; Blanco, Julia.

In: American Journal of Epidemiology, Vol. 150, No. 6, 15.09.1999, p. 590-597.

Research output: Contribution to journalArticle

Borja-Aburto, VH, Hertz-Picciotto, I, Lopez, MR, Farias, P, Rios, C & Blanco, J 1999, 'Blood lead levels measured prospectively and risk of spontaneous abortion', American Journal of Epidemiology, vol. 150, no. 6, pp. 590-597.
Borja-Aburto VH, Hertz-Picciotto I, Lopez MR, Farias P, Rios C, Blanco J. Blood lead levels measured prospectively and risk of spontaneous abortion. American Journal of Epidemiology. 1999 Sep 15;150(6):590-597.
Borja-Aburto, Victor H. ; Hertz-Picciotto, Irva ; Lopez, Magdalena Rojas ; Farias, Paulina ; Rios, Camilo ; Blanco, Julia. / Blood lead levels measured prospectively and risk of spontaneous abortion. In: American Journal of Epidemiology. 1999 ; Vol. 150, No. 6. pp. 590-597.
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