Abstract
Using microarray technology, we investigated whether the gene expression profile in white blood cells could be used as a fingerprint of different disease states. Adult rats were subjected to ischemic strokes, hemorrhagic strokes, sham surgeries, kainate-induced seizures, hypoxia, or insulin-induced hypoglycemia, and compared with controls. The white blood cell RNA expression patterns were assessed 24 hours later using oligonucleotide microarrays. Results showed that many genes were upregulated or downregulated at least twofold in white blood cells after each experimental condition. Blood genomic response patterns were different for each condition. These results demonstrate the potential of blood gene expression profiling for diagnostic, mechanistic, and therapeutic assessment of a wide variety of disease states.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 699-707 |
| Number of pages | 9 |
| Journal | Annals of Neurology |
| Volume | 50 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia : Blood genomic fingerprints of disease. / Tang, Yang; Lu, Aigang; Aronow, Bruce J.; Sharp, Frank R.
In: Annals of Neurology, Vol. 50, No. 6, 2001, p. 699-707.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Blood genomic responses differ after stroke, seizures, hypoglycemia, and hypoxia
T2 - Blood genomic fingerprints of disease
AU - Tang, Yang
AU - Lu, Aigang
AU - Aronow, Bruce J.
AU - Sharp, Frank R
PY - 2001
Y1 - 2001
N2 - Using microarray technology, we investigated whether the gene expression profile in white blood cells could be used as a fingerprint of different disease states. Adult rats were subjected to ischemic strokes, hemorrhagic strokes, sham surgeries, kainate-induced seizures, hypoxia, or insulin-induced hypoglycemia, and compared with controls. The white blood cell RNA expression patterns were assessed 24 hours later using oligonucleotide microarrays. Results showed that many genes were upregulated or downregulated at least twofold in white blood cells after each experimental condition. Blood genomic response patterns were different for each condition. These results demonstrate the potential of blood gene expression profiling for diagnostic, mechanistic, and therapeutic assessment of a wide variety of disease states.
AB - Using microarray technology, we investigated whether the gene expression profile in white blood cells could be used as a fingerprint of different disease states. Adult rats were subjected to ischemic strokes, hemorrhagic strokes, sham surgeries, kainate-induced seizures, hypoxia, or insulin-induced hypoglycemia, and compared with controls. The white blood cell RNA expression patterns were assessed 24 hours later using oligonucleotide microarrays. Results showed that many genes were upregulated or downregulated at least twofold in white blood cells after each experimental condition. Blood genomic response patterns were different for each condition. These results demonstrate the potential of blood gene expression profiling for diagnostic, mechanistic, and therapeutic assessment of a wide variety of disease states.
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UR - http://www.scopus.com/inward/citedby.url?scp=0035205029&partnerID=8YFLogxK
U2 - 10.1002/ana.10042
DO - 10.1002/ana.10042
M3 - Article
C2 - 11761467
AN - SCOPUS:0035205029
VL - 50
SP - 699
EP - 707
JO - Annals of Neurology
JF - Annals of Neurology
SN - 0364-5134
IS - 6
ER -