Blood calcium dynamics after prophylactic treatment of subclinical hypocalcemia with oral or intravenous calcium

C. D. Blanc, M. Van der List, Sharif S Aly, Heidi A Rossow, Noelia Silva Del Rio

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Total serum Ca dynamics and urine pH levels were evaluated after prophylactic treatment of subclinical hypocalcemia after parturition in 33 multiparous Jersey × Holstein crossbreed cows. Cows were blocked according to their calcemic status at the time of treatment [normocalcemic (8.0-9.9mg/dL; n=15) or hypocalcemic (5.0-7.9mg/dL; n=18)] and randomly assigned to 1 of 3 treatments: control [no Ca supplementation (n=11)]; intravenous Ca [Ca-IV (n=11), 500mL of 23% calcium gluconate (10.7g of Ca and 17.5g of boric acid as a solubilizing agent; Durvet, Blue Springs, MO)]; or oral Ca [Ca-Oral (n=11), 1 oral bolus (Bovikalc bolus, Boehringer Ingelheim, St. Joseph, MO) containing CaCl2 and CaSO4 (43g of Ca) 2 times 12h apart]. Total serum Ca levels were evaluated at 0, 1, 2, 4, 8, 12, 16, 20, 24, 36, and 48h, and urine pH was evaluated at 0, 1, 12, 24, 36, and 48h after treatment initiation. Total serum Ca levels were higher for Ca-IV than for control and Ca-Oral cows at 1, 2, and 4h after treatment initiation, but lower than Ca-Oral cows at 20, 24, and 36h and lower than control cows at 36 and 48h. At 1h after treatment initiation, when serum Ca levels for Ca-IV cows peaked (11.4mg/dL), a greater proportion of Ca-IV (n=8) cows had total serum Ca levels >10mg/dL than control (n=0) and Ca-Oral (n=1) cows. At 24h after treatment initiation, when Ca-IV cows reached the total serum Ca nadir (6.4mg/dL), a greater proportion of Ca-IV (n=10) cows had serum Ca levels <8mg/dL than control (n=5) and Ca-Oral (n=2) cows. Treatment, time, and treatment × time interaction were significant for urine pH. Mean urine pH was lower for Ca-Oral cows (6.69) than for control (7.52) and Ca-IV (7.19) cows. Urine pH levels at 1h after treatment were lower for Ca-IV cows compared with both control and Ca-Oral cows, a finding likely associated with the iatrogenic administration of boric acid added as a solubilizing agent of the intravenous Ca solution used. At 12, 24, and 36h, urine pH levels were lower for Ca-Oral cows compared with both control and Ca-IV cows. This was expected because the oral Ca supplementation used (Bovikalc) is designed as an acidifying agent. Wide fluctuations in blood Ca were observed after prophylactic intravenous Ca supplementation. The implications for milk production and animal health, if any, of these transient changes in total serum Ca have yet to be evaluated.

Original languageEnglish (US)
Pages (from-to)6901-6906
Number of pages6
JournalJournal of Dairy Science
Volume97
Issue number11
DOIs
StatePublished - Nov 1 2014

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hypocalcemia
Hypocalcemia
mouth
Calcium
calcium
cows
blood
Urine
Serum
blood serum
urine
Calcium Gluconate
boric acid
solubilization
Milk
Parturition
Health
Jersey

Keywords

  • Calcium homeostasis
  • Hypercalcemia
  • Hypocalcemia

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Food Science
  • Genetics

Cite this

Blood calcium dynamics after prophylactic treatment of subclinical hypocalcemia with oral or intravenous calcium. / Blanc, C. D.; Van der List, M.; Aly, Sharif S; Rossow, Heidi A; Silva Del Rio, Noelia.

In: Journal of Dairy Science, Vol. 97, No. 11, 01.11.2014, p. 6901-6906.

Research output: Contribution to journalArticle

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N2 - Total serum Ca dynamics and urine pH levels were evaluated after prophylactic treatment of subclinical hypocalcemia after parturition in 33 multiparous Jersey × Holstein crossbreed cows. Cows were blocked according to their calcemic status at the time of treatment [normocalcemic (8.0-9.9mg/dL; n=15) or hypocalcemic (5.0-7.9mg/dL; n=18)] and randomly assigned to 1 of 3 treatments: control [no Ca supplementation (n=11)]; intravenous Ca [Ca-IV (n=11), 500mL of 23% calcium gluconate (10.7g of Ca and 17.5g of boric acid as a solubilizing agent; Durvet, Blue Springs, MO)]; or oral Ca [Ca-Oral (n=11), 1 oral bolus (Bovikalc bolus, Boehringer Ingelheim, St. Joseph, MO) containing CaCl2 and CaSO4 (43g of Ca) 2 times 12h apart]. Total serum Ca levels were evaluated at 0, 1, 2, 4, 8, 12, 16, 20, 24, 36, and 48h, and urine pH was evaluated at 0, 1, 12, 24, 36, and 48h after treatment initiation. Total serum Ca levels were higher for Ca-IV than for control and Ca-Oral cows at 1, 2, and 4h after treatment initiation, but lower than Ca-Oral cows at 20, 24, and 36h and lower than control cows at 36 and 48h. At 1h after treatment initiation, when serum Ca levels for Ca-IV cows peaked (11.4mg/dL), a greater proportion of Ca-IV (n=8) cows had total serum Ca levels >10mg/dL than control (n=0) and Ca-Oral (n=1) cows. At 24h after treatment initiation, when Ca-IV cows reached the total serum Ca nadir (6.4mg/dL), a greater proportion of Ca-IV (n=10) cows had serum Ca levels <8mg/dL than control (n=5) and Ca-Oral (n=2) cows. Treatment, time, and treatment × time interaction were significant for urine pH. Mean urine pH was lower for Ca-Oral cows (6.69) than for control (7.52) and Ca-IV (7.19) cows. Urine pH levels at 1h after treatment were lower for Ca-IV cows compared with both control and Ca-Oral cows, a finding likely associated with the iatrogenic administration of boric acid added as a solubilizing agent of the intravenous Ca solution used. At 12, 24, and 36h, urine pH levels were lower for Ca-Oral cows compared with both control and Ca-IV cows. This was expected because the oral Ca supplementation used (Bovikalc) is designed as an acidifying agent. Wide fluctuations in blood Ca were observed after prophylactic intravenous Ca supplementation. The implications for milk production and animal health, if any, of these transient changes in total serum Ca have yet to be evaluated.

AB - Total serum Ca dynamics and urine pH levels were evaluated after prophylactic treatment of subclinical hypocalcemia after parturition in 33 multiparous Jersey × Holstein crossbreed cows. Cows were blocked according to their calcemic status at the time of treatment [normocalcemic (8.0-9.9mg/dL; n=15) or hypocalcemic (5.0-7.9mg/dL; n=18)] and randomly assigned to 1 of 3 treatments: control [no Ca supplementation (n=11)]; intravenous Ca [Ca-IV (n=11), 500mL of 23% calcium gluconate (10.7g of Ca and 17.5g of boric acid as a solubilizing agent; Durvet, Blue Springs, MO)]; or oral Ca [Ca-Oral (n=11), 1 oral bolus (Bovikalc bolus, Boehringer Ingelheim, St. Joseph, MO) containing CaCl2 and CaSO4 (43g of Ca) 2 times 12h apart]. Total serum Ca levels were evaluated at 0, 1, 2, 4, 8, 12, 16, 20, 24, 36, and 48h, and urine pH was evaluated at 0, 1, 12, 24, 36, and 48h after treatment initiation. Total serum Ca levels were higher for Ca-IV than for control and Ca-Oral cows at 1, 2, and 4h after treatment initiation, but lower than Ca-Oral cows at 20, 24, and 36h and lower than control cows at 36 and 48h. At 1h after treatment initiation, when serum Ca levels for Ca-IV cows peaked (11.4mg/dL), a greater proportion of Ca-IV (n=8) cows had total serum Ca levels >10mg/dL than control (n=0) and Ca-Oral (n=1) cows. At 24h after treatment initiation, when Ca-IV cows reached the total serum Ca nadir (6.4mg/dL), a greater proportion of Ca-IV (n=10) cows had serum Ca levels <8mg/dL than control (n=5) and Ca-Oral (n=2) cows. Treatment, time, and treatment × time interaction were significant for urine pH. Mean urine pH was lower for Ca-Oral cows (6.69) than for control (7.52) and Ca-IV (7.19) cows. Urine pH levels at 1h after treatment were lower for Ca-IV cows compared with both control and Ca-Oral cows, a finding likely associated with the iatrogenic administration of boric acid added as a solubilizing agent of the intravenous Ca solution used. At 12, 24, and 36h, urine pH levels were lower for Ca-Oral cows compared with both control and Ca-IV cows. This was expected because the oral Ca supplementation used (Bovikalc) is designed as an acidifying agent. Wide fluctuations in blood Ca were observed after prophylactic intravenous Ca supplementation. The implications for milk production and animal health, if any, of these transient changes in total serum Ca have yet to be evaluated.

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