Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study

Josquin Foiret; Hua Zhang; Brett Z. Fite; Lisa Mahakian; Sarah Tam; David J. Segal; Katherine W Ferrara

doi:10.1109/ULTSYM.2017.8092098

Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study

Josquin Foiret, Hua Zhang, Brett Z. Fite, Lisa Mahakian, Sarah Tam, David J. Segal, Katherine W Ferrara

Biochemistry and Molecular Medicine

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Human studies aimed at opening the blood brain barrier (BBB) to deliver therapeutic agents through a combination of focused ultrasound (US) and microbubbles (MB) are currently underway [1]. Our goal was to develop an US-guided BBB opening system capable of steering the US beam throughout the rodent brain and registering the coordinates with high field MRI. Our ultimate goal is to deliver therapy for Angelman Syndrome which requires the ability to deliver protein or adeno-associated virus (AAV) across the BBB over a large field of view. We sought to interface a modular imaging and therapeutic array capable of 3D electronic steering of the therapeutic beam to the Verasonics and MRI.

Original language	English (US)
Title of host publication	2017 IEEE International Ultrasonics Symposium, IUS 2017
Publisher	IEEE Computer Society
ISBN (Electronic)	9781538633830
DOIs	https://doi.org/10.1109/ULTSYM.2017.8092098
State	Published - Oct 31 2017
Event	2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: Sep 6 2017 → Sep 9 2017

Other

Other	2017 IEEE International Ultrasonics Symposium, IUS 2017
Country	United States
City	Washington
Period	9/6/17 → 9/9/17

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2017.8092098

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Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study. / Foiret, Josquin; Zhang, Hua; Fite, Brett Z.; Mahakian, Lisa; Tam, Sarah; Segal, David J.; Ferrara, Katherine W.

2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8092098.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Foiret, J, Zhang, H, Fite, BZ, Mahakian, L, Tam, S, Segal, DJ & Ferrara, KW 2017, Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study. in 2017 IEEE International Ultrasonics Symposium, IUS 2017., 8092098, IEEE Computer Society, 2017 IEEE International Ultrasonics Symposium, IUS 2017, Washington, United States, 9/6/17. https://doi.org/10.1109/ULTSYM.2017.8092098

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