Abstract
Human studies aimed at opening the blood brain barrier (BBB) to deliver therapeutic agents through a combination of focused ultrasound (US) and microbubbles (MB) are currently underway [1]. Our goal was to develop an US-guided BBB opening system capable of steering the US beam throughout the rodent brain and registering the coordinates with high field MRI. Our ultimate goal is to deliver therapy for Angelman Syndrome which requires the ability to deliver protein or adeno-associated virus (AAV) across the BBB over a large field of view. We sought to interface a modular imaging and therapeutic array capable of 3D electronic steering of the therapeutic beam to the Verasonics and MRI.
Original language | English (US) |
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Title of host publication | 2017 IEEE International Ultrasonics Symposium, IUS 2017 |
Publisher | IEEE Computer Society |
ISBN (Electronic) | 9781538633830 |
DOIs | |
State | Published - Oct 31 2017 |
Externally published | Yes |
Event | 2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: Sep 6 2017 → Sep 9 2017 |
Other
Other | 2017 IEEE International Ultrasonics Symposium, IUS 2017 |
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Country/Territory | United States |
City | Washington |
Period | 9/6/17 → 9/9/17 |
ASJC Scopus subject areas
- Acoustics and Ultrasonics