Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study

Josquin Foiret, Hua Zhang, Brett Z. Fite, Lisa Mahakian, Sarah Tam, David J. Segal, Katherine W Ferrara

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Human studies aimed at opening the blood brain barrier (BBB) to deliver therapeutic agents through a combination of focused ultrasound (US) and microbubbles (MB) are currently underway [1]. Our goal was to develop an US-guided BBB opening system capable of steering the US beam throughout the rodent brain and registering the coordinates with high field MRI. Our ultimate goal is to deliver therapy for Angelman Syndrome which requires the ability to deliver protein or adeno-associated virus (AAV) across the BBB over a large field of view. We sought to interface a modular imaging and therapeutic array capable of 3D electronic steering of the therapeutic beam to the Verasonics and MRI.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period9/6/179/9/17

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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