Abstract
Human studies aimed at opening the blood brain barrier (BBB) to deliver therapeutic agents through a combination of focused ultrasound (US) and microbubbles (MB) are currently underway [1]. Our goal was to develop an US-guided BBB opening system capable of steering the US beam throughout the rodent brain and registering the coordinates with high field MRI. Our ultimate goal is to deliver therapy for Angelman Syndrome which requires the ability to deliver protein or adeno-associated virus (AAV) across the BBB over a large field of view. We sought to interface a modular imaging and therapeutic array capable of 3D electronic steering of the therapeutic beam to the Verasonics and MRI.
| Original language | English (US) |
|---|---|
| Title of host publication | 2017 IEEE International Ultrasonics Symposium, IUS 2017 |
| Publisher | IEEE Computer Society |
| ISBN (Electronic) | 9781538633830 |
| DOIs | |
| State | Published - Oct 31 2017 |
| Event | 2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States Duration: Sep 6 2017 → Sep 9 2017 |
Other
| Other | 2017 IEEE International Ultrasonics Symposium, IUS 2017 |
|---|---|
| Country | United States |
| City | Washington |
| Period | 9/6/17 → 9/9/17 |
Fingerprint
ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study. / Foiret, Josquin; Zhang, Hua; Fite, Brett Z.; Mahakian, Lisa; Tam, Sarah; Segal, David; Ferrara, Katherine W.
2017 IEEE International Ultrasonics Symposium, IUS 2017. IEEE Computer Society, 2017. 8092098.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Blood-brain barrier disruption for the delivery of non-infectious viral vectors and proteins, preliminary study
AU - Foiret, Josquin
AU - Zhang, Hua
AU - Fite, Brett Z.
AU - Mahakian, Lisa
AU - Tam, Sarah
AU - Segal, David
AU - Ferrara, Katherine W.
PY - 2017/10/31
Y1 - 2017/10/31
N2 - Human studies aimed at opening the blood brain barrier (BBB) to deliver therapeutic agents through a combination of focused ultrasound (US) and microbubbles (MB) are currently underway [1]. Our goal was to develop an US-guided BBB opening system capable of steering the US beam throughout the rodent brain and registering the coordinates with high field MRI. Our ultimate goal is to deliver therapy for Angelman Syndrome which requires the ability to deliver protein or adeno-associated virus (AAV) across the BBB over a large field of view. We sought to interface a modular imaging and therapeutic array capable of 3D electronic steering of the therapeutic beam to the Verasonics and MRI.
AB - Human studies aimed at opening the blood brain barrier (BBB) to deliver therapeutic agents through a combination of focused ultrasound (US) and microbubbles (MB) are currently underway [1]. Our goal was to develop an US-guided BBB opening system capable of steering the US beam throughout the rodent brain and registering the coordinates with high field MRI. Our ultimate goal is to deliver therapy for Angelman Syndrome which requires the ability to deliver protein or adeno-associated virus (AAV) across the BBB over a large field of view. We sought to interface a modular imaging and therapeutic array capable of 3D electronic steering of the therapeutic beam to the Verasonics and MRI.
UR - http://www.scopus.com/inward/record.url?scp=85039428209&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039428209&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2017.8092098
DO - 10.1109/ULTSYM.2017.8092098
M3 - Conference contribution
BT - 2017 IEEE International Ultrasonics Symposium, IUS 2017
PB - IEEE Computer Society
ER -