Blockade of B2 receptors attenuates the responses of group III afferents to static contraction

Anna K. Leal, Audrey J. Stone, Katsuya Yamauchi, Jennifer L. McCord, Marc P Kaufman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Recent evidence has been presented demonstrating that group III mechanoreceptors comprise an important part of the sensory arm of the exercise pressor reflex, which in turn functions to increase arterial blood flow to contracting skeletal muscles. Although group III afferents are stimulated by mechanical distortion of their receptive fields, they are also stimulated by bradykinin, which is produced by skeletal muscle when it contracts. Moreover, blockade of B (bradykinin)2 receptors has been shown to decrease the magnitude of the exercise pressor reflex. Nevertheless, the effect of blockade of B2 receptors on responses of group III afferents to contraction is not known. We therefore determined the effect of B2 receptor blockade with HOE 140 (40μg/kg) on the responses to both static and intermittent contraction of group III afferents with endings in the triceps surae muscle of decerebrated unanesthetized cats. We found that HOE 140 significantly attenuated (P=0.04) the responses of 14 group III afferents to static contraction, but did not significantly attenuate (P=0.16) the responses of 16 group III afferents to intermittent contraction. The attenuation induced by HOE 140 was present throughout the static contraction period, and led us to speculate that blockade of B2 receptors on the endings of group III afferents decreased their sensitivity to mechanical events occurring in the working muscles.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalNeuroscience Letters
Volume555
DOIs
StatePublished - Oct 25 2013
Externally publishedYes

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Reflex
Skeletal Muscle
Bradykinin Receptors
Muscles
Mechanoreceptors
Bradykinin
Cats
icatibant

Keywords

  • Bradykinin
  • Exercise pressor reflex
  • HOE 140
  • Locomotion
  • Mechanoreception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)

Cite this

Blockade of B2 receptors attenuates the responses of group III afferents to static contraction. / Leal, Anna K.; Stone, Audrey J.; Yamauchi, Katsuya; McCord, Jennifer L.; Kaufman, Marc P.

In: Neuroscience Letters, Vol. 555, 25.10.2013, p. 231-236.

Research output: Contribution to journalArticle

Leal, Anna K. ; Stone, Audrey J. ; Yamauchi, Katsuya ; McCord, Jennifer L. ; Kaufman, Marc P. / Blockade of B2 receptors attenuates the responses of group III afferents to static contraction. In: Neuroscience Letters. 2013 ; Vol. 555. pp. 231-236.
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