Bleomycin-induced pulmonary fibrosis: Correlation of biochemical, physiological, and histological changes

Thomas W. Hesterberg, Joan E. Gerriets, Karen M. Reiser, Andrew C. Jackson, Carroll E Cross, Jerold A Last

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Rats (275-300 g) were intratracheally instilled with 0.38, 0.75, or 1.5 units of bleomycin sulfate. One, two, and three weeks later lung damage was evaluated using a variety of indices, including body weight, right apical lung lobe wet weight, protein- and collagen-synthesis rates by lung minces, lung hydroxyproline content, lung compliance, and lung histology. Several parameters in the high-dose bleomycin group also were evaluated 5 and 8 weeks after instillation. Most of the assays showed a dose-response effect. However, biochemical assays did not correlate with physiological changes 5 and 8 weeks after instillation.

Original languageEnglish (US)
Pages (from-to)360-367
Number of pages8
JournalToxicology and Applied Pharmacology
Volume60
Issue number2
DOIs
StatePublished - Sep 15 1981

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Pulmonary Fibrosis
Bleomycin
Assays
Lung
Histology
Hydroxyproline
Rats
Collagen
Lung Compliance
Pulmonary Edema
Proteins
Body Weight
Weights and Measures
Compliance

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Bleomycin-induced pulmonary fibrosis : Correlation of biochemical, physiological, and histological changes. / Hesterberg, Thomas W.; Gerriets, Joan E.; Reiser, Karen M.; Jackson, Andrew C.; Cross, Carroll E; Last, Jerold A.

In: Toxicology and Applied Pharmacology, Vol. 60, No. 2, 15.09.1981, p. 360-367.

Research output: Contribution to journalArticle

Hesterberg, Thomas W. ; Gerriets, Joan E. ; Reiser, Karen M. ; Jackson, Andrew C. ; Cross, Carroll E ; Last, Jerold A. / Bleomycin-induced pulmonary fibrosis : Correlation of biochemical, physiological, and histological changes. In: Toxicology and Applied Pharmacology. 1981 ; Vol. 60, No. 2. pp. 360-367.
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