Bleomycin-induced pulmonary fibrosis: Correlation of biochemical, physiological, and histological changes

Thomas W. Hesterberg, Joan E. Gerriets, Karen M. Reiser, Andrew C. Jackson, Carroll E Cross, Jerold A Last

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Rats (275-300 g) were intratracheally instilled with 0.38, 0.75, or 1.5 units of bleomycin sulfate. One, two, and three weeks later lung damage was evaluated using a variety of indices, including body weight, right apical lung lobe wet weight, protein- and collagen-synthesis rates by lung minces, lung hydroxyproline content, lung compliance, and lung histology. Several parameters in the high-dose bleomycin group also were evaluated 5 and 8 weeks after instillation. Most of the assays showed a dose-response effect. However, biochemical assays did not correlate with physiological changes 5 and 8 weeks after instillation.

Original languageEnglish (US)
Pages (from-to)360-367
Number of pages8
JournalToxicology and Applied Pharmacology
Volume60
Issue number2
DOIs
StatePublished - Sep 15 1981

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ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

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