Abstract
Rats (275-300 g) were intratracheally instilled with 0.38, 0.75, or 1.5 units of bleomycin sulfate. One, two, and three weeks later lung damage was evaluated using a variety of indices, including body weight, right apical lung lobe wet weight, protein- and collagen-synthesis rates by lung minces, lung hydroxyproline content, lung compliance, and lung histology. Several parameters in the high-dose bleomycin group also were evaluated 5 and 8 weeks after instillation. Most of the assays showed a dose-response effect. However, biochemical assays did not correlate with physiological changes 5 and 8 weeks after instillation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 360-367 |
| Number of pages | 8 |
| Journal | Toxicology and Applied Pharmacology |
| Volume | 60 |
| Issue number | 2 |
| DOIs | |
| State | Published - Sep 15 1981 |
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ASJC Scopus subject areas
- Pharmacology
- Toxicology
Cite this
Bleomycin-induced pulmonary fibrosis : Correlation of biochemical, physiological, and histological changes. / Hesterberg, Thomas W.; Gerriets, Joan E.; Reiser, Karen M.; Jackson, Andrew C.; Cross, Carroll E; Last, Jerold A.
In: Toxicology and Applied Pharmacology, Vol. 60, No. 2, 15.09.1981, p. 360-367.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bleomycin-induced pulmonary fibrosis
T2 - Correlation of biochemical, physiological, and histological changes
AU - Hesterberg, Thomas W.
AU - Gerriets, Joan E.
AU - Reiser, Karen M.
AU - Jackson, Andrew C.
AU - Cross, Carroll E
AU - Last, Jerold A
PY - 1981/9/15
Y1 - 1981/9/15
N2 - Rats (275-300 g) were intratracheally instilled with 0.38, 0.75, or 1.5 units of bleomycin sulfate. One, two, and three weeks later lung damage was evaluated using a variety of indices, including body weight, right apical lung lobe wet weight, protein- and collagen-synthesis rates by lung minces, lung hydroxyproline content, lung compliance, and lung histology. Several parameters in the high-dose bleomycin group also were evaluated 5 and 8 weeks after instillation. Most of the assays showed a dose-response effect. However, biochemical assays did not correlate with physiological changes 5 and 8 weeks after instillation.
AB - Rats (275-300 g) were intratracheally instilled with 0.38, 0.75, or 1.5 units of bleomycin sulfate. One, two, and three weeks later lung damage was evaluated using a variety of indices, including body weight, right apical lung lobe wet weight, protein- and collagen-synthesis rates by lung minces, lung hydroxyproline content, lung compliance, and lung histology. Several parameters in the high-dose bleomycin group also were evaluated 5 and 8 weeks after instillation. Most of the assays showed a dose-response effect. However, biochemical assays did not correlate with physiological changes 5 and 8 weeks after instillation.
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UR - http://www.scopus.com/inward/citedby.url?scp=0019451552&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(91)90239-B
DO - 10.1016/0041-008X(91)90239-B
M3 - Article
C2 - 6169174
AN - SCOPUS:0019451552
VL - 60
SP - 360
EP - 367
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
SN - 0041-008X
IS - 2
ER -