Bleomycin-induced pulmonary fibrosis: Correlation of biochemical, physiological, and histological changes

Thomas W. Hesterberg; Joan E. Gerriets; Karen M. Reiser; Andrew C. Jackson; Carroll E Cross; Jerold A Last

doi:10.1016/0041-008X(91)90239-B

Bleomycin-induced pulmonary fibrosis: Correlation of biochemical, physiological, and histological changes

Thomas W. Hesterberg, Joan E. Gerriets, Karen M. Reiser, Andrew C. Jackson, Carroll E Cross, Jerold A Last

Pulmonary, Critical Care, and Sleep Medicine

Research output: Contribution to journal › Article

49 Scopus citations

Abstract

Rats (275-300 g) were intratracheally instilled with 0.38, 0.75, or 1.5 units of bleomycin sulfate. One, two, and three weeks later lung damage was evaluated using a variety of indices, including body weight, right apical lung lobe wet weight, protein- and collagen-synthesis rates by lung minces, lung hydroxyproline content, lung compliance, and lung histology. Several parameters in the high-dose bleomycin group also were evaluated 5 and 8 weeks after instillation. Most of the assays showed a dose-response effect. However, biochemical assays did not correlate with physiological changes 5 and 8 weeks after instillation.

Original language	English (US)
Pages (from-to)	360-367
Number of pages	8
Journal	Toxicology and Applied Pharmacology
Volume	60
Issue number	2
DOIs	https://doi.org/10.1016/0041-008X(91)90239-B
State	Published - Sep 15 1981

ASJC Scopus subject areas

Pharmacology
Toxicology

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Hesterberg, T. W., Gerriets, J. E., Reiser, K. M., Jackson, A. C., Cross, C. E., & Last, J. A. (1981). Bleomycin-induced pulmonary fibrosis: Correlation of biochemical, physiological, and histological changes. Toxicology and Applied Pharmacology, 60(2), 360-367. https://doi.org/10.1016/0041-008X(91)90239-B

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