Abstract
A new bifunctional chelating agent, (S)-1-(p-bromoacetamidobenzyl) ethylenedinitrilotetraacetic acid, has been prepared from L-phenylalanine. Reaction of the chelating agent with the Co(III) complex of the antitumor antibody bleomycin-A2DM was used to generate a new derivative of Co(III)-bleomyin, BLEDTA II. The product can be radiolabeled quickly by binding a radioactive metal ion to the EDTA group. The in vivo distribution of 111In-BLEDTA II in tumor-bearing mice was determined and found to be indistinguishable from that of the clinically useful 111In(III)-BLEDTA I complex.
Original language | English (US) |
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Pages (from-to) | 1517-1534 |
Number of pages | 18 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 18 |
Issue number | 10 |
State | Published - 1981 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Medicine
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology