Abstract
A new bifunctional chelating agent, (S)-1-(p-bromoacetamidobenzyl) ethylenedinitrilotetraacetic acid, has been prepared from L-phenylalanine. Reaction of the chelating agent with the Co(III) complex of the antitumor antibody bleomycin-A2DM was used to generate a new derivative of Co(III)-bleomyin, BLEDTA II. The product can be radiolabeled quickly by binding a radioactive metal ion to the EDTA group. The in vivo distribution of 111In-BLEDTA II in tumor-bearing mice was determined and found to be indistinguishable from that of the clinically useful 111In(III)-BLEDTA I complex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1517-1534 |
| Number of pages | 18 |
| Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
| Volume | 18 |
| Issue number | 10 |
| State | Published - 1981 |
ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Medicine
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology
Fingerprint Dive into the research topics of 'BLEDTA II: Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin'. Together they form a unique fingerprint.
Cite this
DeRiemer, L. H., Meares, C. F., Goodwin, D. A., & Diamanti, C. I. (1981). BLEDTA II: Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin. Journal of Labelled Compounds and Radiopharmaceuticals, 18(10), 1517-1534.