BLEDTA II: Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin

L. H. DeRiemer, C. F. Meares, D. A. Goodwin, C. I. Diamanti

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

A new bifunctional chelating agent, (S)-1-(p-bromoacetamidobenzyl) ethylenedinitrilotetraacetic acid, has been prepared from L-phenylalanine. Reaction of the chelating agent with the Co(III) complex of the antitumor antibody bleomycin-A2DM was used to generate a new derivative of Co(III)-bleomyin, BLEDTA II. The product can be radiolabeled quickly by binding a radioactive metal ion to the EDTA group. The in vivo distribution of 111In-BLEDTA II in tumor-bearing mice was determined and found to be indistinguishable from that of the clinically useful 111In(III)-BLEDTA I complex.

Original languageEnglish (US)
Pages (from-to)1517-1534
Number of pages18
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume18
Issue number10
StatePublished - 1981

Fingerprint

Bleomycin
Tumors
Chelating Agents
Derivatives
Edetic Acid
Bearings (structural)
Neoplasms
Phenylalanine
Metal ions
Metals
Ions
Antibodies
BLEDTA

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

DeRiemer, L. H., Meares, C. F., Goodwin, D. A., & Diamanti, C. I. (1981). BLEDTA II: Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin. Journal of Labelled Compounds and Radiopharmaceuticals, 18(10), 1517-1534.

BLEDTA II : Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin. / DeRiemer, L. H.; Meares, C. F.; Goodwin, D. A.; Diamanti, C. I.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 18, No. 10, 1981, p. 1517-1534.

Research output: Contribution to journalArticle

DeRiemer, LH, Meares, CF, Goodwin, DA & Diamanti, CI 1981, 'BLEDTA II: Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 18, no. 10, pp. 1517-1534.
DeRiemer, L. H. ; Meares, C. F. ; Goodwin, D. A. ; Diamanti, C. I. / BLEDTA II : Synthesis of a new tumor-visualizing derivative of Co(III)-bleomycin. In: Journal of Labelled Compounds and Radiopharmaceuticals. 1981 ; Vol. 18, No. 10. pp. 1517-1534.
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