Blastomycosis in nondomestic felids

Timothy N. Storms, Victoria L. Clyde, Linda Munson, Edward C. Ramsay

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Blastomycosis was diagnosed in six nondomestic felids from eastern Tennessee, including two Asian lions (Panthera leo persicus), one African lion (Panthera leo), one Siberian tiger (Panthera tigris), one cheetah (Acinonyx jubatus), and one snow leopard (Panthera uncia). Clinical signs included lethargy, anorexia, weight loss, dyspnea, sneezing, ataxia, and paresis. Variable nonspecific changes included leukocytosis, monocytosis, moderate left shift of neutrophils, moderate hypercalcemia, hyperproteinemia, and hyperglobulinemia. Thoracic radiographs revealed interstitial and alveolar changes, consolidation or collapse of a lung lobe, bullae formation, and a pulmonary mass. Agar gel immunodiffusion (AGID) serology for Blastomyces dermatitidis was performed in five felids and was positive in three. The tiger had cerebral blastomycosis and was positive for AGID serologic tests of both cerebrospinal fluid and serum. One percutaneous lung aspirate in the snow leopard and one bronchial aspirate in an Asian lion demonstrated B. dermatitidis organisms, whereas tracheal wash samples and a nasal discharge were nondiagnostic in others. Treatment with itraconazole was attempted in four cats. The tiger improved before euthanasia, whereas the others did not survive beyond initial treatments. In four felids, B. dermatitidis was found in the lungs and tracheobronchial lymph nodes, associated with a florid pyogranulomatous reaction; the tiger had a pyogranulomatous encephalomyelitis, and the cheetah had a single pulmonary granuloma. Thoracic radiography, cytologic examination of lung lesion aspirates, and B. dermatitidis AGID serology should be performed on clinically ill zoo felids in endemic areas to rule out blastomycosis.

Original languageEnglish (US)
Pages (from-to)231-238
Number of pages8
JournalJournal of Zoo and Wildlife Medicine
Volume34
Issue number3
StatePublished - Sep 2003
Externally publishedYes

Fingerprint

Blastomycosis
Lions
blastomycosis
Tigers
felid
Blastomyces
Felidae
Acinonyx
Blastomyces dermatitidis
Panthera leo
Panthera tigris
lungs
Panthera uncia
agar
Immunodiffusion
Acinonyx jubatus
Lung
gel
Agar
Gels

Keywords

  • Acinonyx jubatus
  • Blastomyces dermatitidis
  • Blastomycosis
  • Nondomestic felid
  • Panthera sp.

ASJC Scopus subject areas

  • Environmental Science(all)
  • Animal Science and Zoology
  • veterinary(all)

Cite this

Storms, T. N., Clyde, V. L., Munson, L., & Ramsay, E. C. (2003). Blastomycosis in nondomestic felids. Journal of Zoo and Wildlife Medicine, 34(3), 231-238.

Blastomycosis in nondomestic felids. / Storms, Timothy N.; Clyde, Victoria L.; Munson, Linda; Ramsay, Edward C.

In: Journal of Zoo and Wildlife Medicine, Vol. 34, No. 3, 09.2003, p. 231-238.

Research output: Contribution to journalArticle

Storms, TN, Clyde, VL, Munson, L & Ramsay, EC 2003, 'Blastomycosis in nondomestic felids', Journal of Zoo and Wildlife Medicine, vol. 34, no. 3, pp. 231-238.
Storms TN, Clyde VL, Munson L, Ramsay EC. Blastomycosis in nondomestic felids. Journal of Zoo and Wildlife Medicine. 2003 Sep;34(3):231-238.
Storms, Timothy N. ; Clyde, Victoria L. ; Munson, Linda ; Ramsay, Edward C. / Blastomycosis in nondomestic felids. In: Journal of Zoo and Wildlife Medicine. 2003 ; Vol. 34, No. 3. pp. 231-238.
@article{a31f53467905400da16962aaa734b433,
title = "Blastomycosis in nondomestic felids",
abstract = "Blastomycosis was diagnosed in six nondomestic felids from eastern Tennessee, including two Asian lions (Panthera leo persicus), one African lion (Panthera leo), one Siberian tiger (Panthera tigris), one cheetah (Acinonyx jubatus), and one snow leopard (Panthera uncia). Clinical signs included lethargy, anorexia, weight loss, dyspnea, sneezing, ataxia, and paresis. Variable nonspecific changes included leukocytosis, monocytosis, moderate left shift of neutrophils, moderate hypercalcemia, hyperproteinemia, and hyperglobulinemia. Thoracic radiographs revealed interstitial and alveolar changes, consolidation or collapse of a lung lobe, bullae formation, and a pulmonary mass. Agar gel immunodiffusion (AGID) serology for Blastomyces dermatitidis was performed in five felids and was positive in three. The tiger had cerebral blastomycosis and was positive for AGID serologic tests of both cerebrospinal fluid and serum. One percutaneous lung aspirate in the snow leopard and one bronchial aspirate in an Asian lion demonstrated B. dermatitidis organisms, whereas tracheal wash samples and a nasal discharge were nondiagnostic in others. Treatment with itraconazole was attempted in four cats. The tiger improved before euthanasia, whereas the others did not survive beyond initial treatments. In four felids, B. dermatitidis was found in the lungs and tracheobronchial lymph nodes, associated with a florid pyogranulomatous reaction; the tiger had a pyogranulomatous encephalomyelitis, and the cheetah had a single pulmonary granuloma. Thoracic radiography, cytologic examination of lung lesion aspirates, and B. dermatitidis AGID serology should be performed on clinically ill zoo felids in endemic areas to rule out blastomycosis.",
keywords = "Acinonyx jubatus, Blastomyces dermatitidis, Blastomycosis, Nondomestic felid, Panthera sp.",
author = "Storms, {Timothy N.} and Clyde, {Victoria L.} and Linda Munson and Ramsay, {Edward C.}",
year = "2003",
month = "9",
language = "English (US)",
volume = "34",
pages = "231--238",
journal = "Journal of Zoo and Wildlife Medicine",
issn = "1042-7260",
publisher = "American Association of Zoo Veterinarians",
number = "3",

}

TY - JOUR

T1 - Blastomycosis in nondomestic felids

AU - Storms, Timothy N.

AU - Clyde, Victoria L.

AU - Munson, Linda

AU - Ramsay, Edward C.

PY - 2003/9

Y1 - 2003/9

N2 - Blastomycosis was diagnosed in six nondomestic felids from eastern Tennessee, including two Asian lions (Panthera leo persicus), one African lion (Panthera leo), one Siberian tiger (Panthera tigris), one cheetah (Acinonyx jubatus), and one snow leopard (Panthera uncia). Clinical signs included lethargy, anorexia, weight loss, dyspnea, sneezing, ataxia, and paresis. Variable nonspecific changes included leukocytosis, monocytosis, moderate left shift of neutrophils, moderate hypercalcemia, hyperproteinemia, and hyperglobulinemia. Thoracic radiographs revealed interstitial and alveolar changes, consolidation or collapse of a lung lobe, bullae formation, and a pulmonary mass. Agar gel immunodiffusion (AGID) serology for Blastomyces dermatitidis was performed in five felids and was positive in three. The tiger had cerebral blastomycosis and was positive for AGID serologic tests of both cerebrospinal fluid and serum. One percutaneous lung aspirate in the snow leopard and one bronchial aspirate in an Asian lion demonstrated B. dermatitidis organisms, whereas tracheal wash samples and a nasal discharge were nondiagnostic in others. Treatment with itraconazole was attempted in four cats. The tiger improved before euthanasia, whereas the others did not survive beyond initial treatments. In four felids, B. dermatitidis was found in the lungs and tracheobronchial lymph nodes, associated with a florid pyogranulomatous reaction; the tiger had a pyogranulomatous encephalomyelitis, and the cheetah had a single pulmonary granuloma. Thoracic radiography, cytologic examination of lung lesion aspirates, and B. dermatitidis AGID serology should be performed on clinically ill zoo felids in endemic areas to rule out blastomycosis.

AB - Blastomycosis was diagnosed in six nondomestic felids from eastern Tennessee, including two Asian lions (Panthera leo persicus), one African lion (Panthera leo), one Siberian tiger (Panthera tigris), one cheetah (Acinonyx jubatus), and one snow leopard (Panthera uncia). Clinical signs included lethargy, anorexia, weight loss, dyspnea, sneezing, ataxia, and paresis. Variable nonspecific changes included leukocytosis, monocytosis, moderate left shift of neutrophils, moderate hypercalcemia, hyperproteinemia, and hyperglobulinemia. Thoracic radiographs revealed interstitial and alveolar changes, consolidation or collapse of a lung lobe, bullae formation, and a pulmonary mass. Agar gel immunodiffusion (AGID) serology for Blastomyces dermatitidis was performed in five felids and was positive in three. The tiger had cerebral blastomycosis and was positive for AGID serologic tests of both cerebrospinal fluid and serum. One percutaneous lung aspirate in the snow leopard and one bronchial aspirate in an Asian lion demonstrated B. dermatitidis organisms, whereas tracheal wash samples and a nasal discharge were nondiagnostic in others. Treatment with itraconazole was attempted in four cats. The tiger improved before euthanasia, whereas the others did not survive beyond initial treatments. In four felids, B. dermatitidis was found in the lungs and tracheobronchial lymph nodes, associated with a florid pyogranulomatous reaction; the tiger had a pyogranulomatous encephalomyelitis, and the cheetah had a single pulmonary granuloma. Thoracic radiography, cytologic examination of lung lesion aspirates, and B. dermatitidis AGID serology should be performed on clinically ill zoo felids in endemic areas to rule out blastomycosis.

KW - Acinonyx jubatus

KW - Blastomyces dermatitidis

KW - Blastomycosis

KW - Nondomestic felid

KW - Panthera sp.

UR - http://www.scopus.com/inward/record.url?scp=0242409424&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242409424&partnerID=8YFLogxK

M3 - Article

C2 - 14582783

AN - SCOPUS:0242409424

VL - 34

SP - 231

EP - 238

JO - Journal of Zoo and Wildlife Medicine

JF - Journal of Zoo and Wildlife Medicine

SN - 1042-7260

IS - 3

ER -