Black phosphorus nanosheets-based stable drug delivery system via drug-self-stabilization for combined photothermal and chemo cancer therapy

Gan Liu, Hsiang I. Tsai, Xiaowei Zeng, Junyang Qi, Miaomiao Luo, Xusheng Wang, Lin Mei, Wenbin Deng

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Black phosphorus (BP) nanomaterials have shown great potential as near-infrared (NIR) photothermal therapy agents and drug delivery systems for cancer therapy. However, their practical applications were still severely limited as their lack of stability under ambient conditions. Here we reported a strategy of using drug itself to stabilize BP. The active species of platinum-based anticancer drugs (DACHPt and Pt(NH3)2) were utilized to coordinate with BP nanosheets to form complex BP/DACHPt and BP/Pt(NH3)2 and improve their stability. BP nanosheets were proved to load DACHPt twice their weight and released it in acid- and NIR-responsive manner, indicating an excellent drug carrier. In vitro cytotoxicity results and apoptosis mechanism showed BP/DACHPt would almost kill all the cancer cells by combined photothermal and chemo effects. Finally in vivo results confirmed BP/DACHPt-PEG would accumulate efficiently in tumor and exert tumor ablation. Thus this novel strategy of using drug itself to stabilize BP, would not only evade the potential clinical application risks, but also construct stable BP-based drug delivery system for combined photothermal and chemo cancer therapy.

Original languageEnglish (US)
Article number121917
JournalChemical Engineering Journal
DOIs
StatePublished - Nov 1 2019

Fingerprint

Nanosheets
Phosphorus
cancer
stabilization
drug
Stabilization
phosphorus
Pharmaceutical Preparations
tumor
Tumors
near infrared
Drug Delivery Systems
therapy
Infrared radiation
Drug Carriers
apoptosis
Cell death
Cytotoxicity
Ablation
Platinum

Keywords

  • Black phosphorus
  • Combined cancer therapy
  • Drug-self-stabilization
  • Enhanced stability
  • Platinum-based anticancer drugs

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

Cite this

Black phosphorus nanosheets-based stable drug delivery system via drug-self-stabilization for combined photothermal and chemo cancer therapy. / Liu, Gan; Tsai, Hsiang I.; Zeng, Xiaowei; Qi, Junyang; Luo, Miaomiao; Wang, Xusheng; Mei, Lin; Deng, Wenbin.

In: Chemical Engineering Journal, 01.11.2019.

Research output: Contribution to journalArticle

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AU - Qi, Junyang

AU - Luo, Miaomiao

AU - Wang, Xusheng

AU - Mei, Lin

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