Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys: Relevance for human exposures

Frederick S. Vom Saal, Catherine A. Vandevoort, Julia A. Taylor, Wade V. Welshons, Pierre Louis Toutain, Patricia A. Hunt

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

We measured serum dBPA in non-pregnant and pregnant female rhesus monkeys, fetuses and amniotic fluid. dBPA was administered by a daily oral bolus or sc implantation of Silastic capsules; both resulted in daily average serum unconjugated dBPA concentrations of <1. ng/ml. We observed lower serum concentrations of unconjugated dBPA in pregnant females relative to pre-pregnancy values, and generally lower concentrations in fetal serum than in maternal serum. Differences in pharmacokinetics of dBPA were evident between pre-pregnancy, early and late pregnancy, likely reflecting changes in maternal, fetal and placental physiology. The serum ratio of conjugated to unconjugated dBPA after continuous sc release of dBPA was similar to values reported in human biomonitoring studies and markedly lower than with oral administration, suggesting oral bolus exposure is not an appropriate human exposure model. We report elsewhere that there were numerous adverse effects on fetuses exposed to very low serum dBPA in these studies.

Original languageEnglish (US)
Pages (from-to)105-116
Number of pages12
JournalReproductive Toxicology
Volume45
DOIs
StatePublished - 2014

Fingerprint

Pharmacokinetics
Physiology
Macaca mulatta
Capsules
Fluids
Serum
Pregnancy
Fetus
Mothers
Environmental Monitoring
Amniotic Fluid
bisphenol A
baysilon
Oral Administration

Keywords

  • Bisphenol A
  • Fetus
  • Maternal
  • Pharmacokinetics
  • Pregnancy
  • Rhesus monkey

ASJC Scopus subject areas

  • Toxicology
  • Medicine(all)

Cite this

Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys : Relevance for human exposures. / Vom Saal, Frederick S.; Vandevoort, Catherine A.; Taylor, Julia A.; Welshons, Wade V.; Toutain, Pierre Louis; Hunt, Patricia A.

In: Reproductive Toxicology, Vol. 45, 2014, p. 105-116.

Research output: Contribution to journalArticle

Vom Saal, Frederick S. ; Vandevoort, Catherine A. ; Taylor, Julia A. ; Welshons, Wade V. ; Toutain, Pierre Louis ; Hunt, Patricia A. / Bisphenol A (BPA) pharmacokinetics with daily oral bolus or continuous exposure via silastic capsules in pregnant rhesus monkeys : Relevance for human exposures. In: Reproductive Toxicology. 2014 ; Vol. 45. pp. 105-116.
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AU - Taylor, Julia A.

AU - Welshons, Wade V.

AU - Toutain, Pierre Louis

AU - Hunt, Patricia A.

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