Biotin deficiency in the cat and the effect of hepatic propionyl CoA carboxylase

C. J. Carey, James Morris

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Biotin deficiency was produced in growing kittens by feeding a diet containing dried, raw egg white. After receiving either an 18.5% egg white diet for 25 weeks, or a 32% egg white diet for 12 weeks, they exhibited dermal lesions characterized by alopecia, scaly dermatitis and achromotrichia, which increased in severity with the deficiency. Females developed accumulations of dried salivary, nasal and lacrymal secretions in the facial region although a male did not. There was a loss of body weight in all cats as the deficiency progressed. Hepatic propionyl CoA carboxylase activities were measured on biopsy samples of liver during biotin deficiency and after biotin supplementation. In the deficient state, activities were 4% and 24% of that following biotin supplementation. Propionyl carboxylase activity in the liver of the cat was comparable to that reported in the rat and chick in the deficient and normal states. Subcutaneous injection of 0.25 mg biotin every other day while continuing to receive the egg white diet, caused remission of clinical signs, a body weight gain and increased food intake.

Original languageEnglish (US)
Pages (from-to)330-334
Number of pages5
JournalJournal of Nutrition
Volume107
Issue number2
StatePublished - Jan 1 1977

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propionyl-CoA carboxylase
Methylmalonyl-CoA Decarboxylase
Egg White
biotin
egg albumen
Cats
Biotin
cats
Diet
liver
Liver
diet
Body Weight
raw eggs
Alopecia
Dermatitis
Subcutaneous Injections
Nose
body weight
alopecia

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)

Cite this

Biotin deficiency in the cat and the effect of hepatic propionyl CoA carboxylase. / Carey, C. J.; Morris, James.

In: Journal of Nutrition, Vol. 107, No. 2, 01.01.1977, p. 330-334.

Research output: Contribution to journalArticle

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