Biosensors for Cell Analysis

Qing Zhou, Kyungjin Son, Ying Liu, Alexander Revzin

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Biosensors first appeared several decades ago to address the need for monitoring physiological parameters such as oxygen or glucose in biological fluids such as blood. More recently, a new wave of biosensors has emerged in order to provide more nuanced and granular information about the composition and function of living cells. Such biosensors exist at the confluence of technology and medicine and often strive to connect cell phenotype or function to physiological or pathophysiological processes. Our review aims to describe some of the key technological aspects of biosensors being developed for cell analysis. The technological aspects covered in our review include biorecognition elements used for biosensor construction, methods for integrating cells with biosensors, approaches to single-cell analysis, and the use of nanostructured biosensors for cell analysis. Our hope is that the spectrum of possibilities for cell analysis described in this review may pique the interest of biomedical scientists and engineers and may spur new collaborations in the area of using biosensors for cell analysis.

Original languageEnglish (US)
Pages (from-to)165-190
Number of pages26
JournalAnnual Review of Biomedical Engineering
Volume17
DOIs
StatePublished - Dec 7 2015

Fingerprint

Biosensing Techniques
Biosensors
Single-Cell Analysis
Physiologic Monitoring
Medicine
Glucose
Blood
Cells
Oxygen
Technology
Phenotype
Engineers
Fluids
Monitoring
Chemical analysis

Keywords

  • Biosensors
  • Cytokine detection
  • Microsystems
  • Nanosensors
  • Paracrine interactions
  • Single-cell analysis

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Biosensors for Cell Analysis. / Zhou, Qing; Son, Kyungjin; Liu, Ying; Revzin, Alexander.

In: Annual Review of Biomedical Engineering, Vol. 17, 07.12.2015, p. 165-190.

Research output: Contribution to journalReview article

Zhou, Qing ; Son, Kyungjin ; Liu, Ying ; Revzin, Alexander. / Biosensors for Cell Analysis. In: Annual Review of Biomedical Engineering. 2015 ; Vol. 17. pp. 165-190.
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