Bioreactors for guiding muscle tissue growth and development

R. G. Dennis, B. Smith, A. Philp, K. Donnelly, Keith Baar

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Muscle tissue bioreactors are devices which are employed to guide and monitor the development of engineered muscle tissue. These devices have a modern history that can be traced back more than a century, because the key elements of muscle tissue bioreactors have been studied for a very long time. These include barrier isolation and culture of cells, tissues and organs after isolation from a host organism; the provision of various stimuli intended to promote growth and maintain the muscle, such as electrical and mechanical stimulation; and the provision of a perfusate such as culture media or blood derived substances. An accurate appraisal of our current progress in the development of muscle bioreactors can only be made in the context of the history of this endeavor. Modern efforts tend to focus more upon the use of computer control and the application of mechanical strain as a stimulus, as well as substrate surface modifications to induce cellular organization at the early stages of culture of isolated muscle cells.

Original languageEnglish (US)
Pages (from-to)39-79
Number of pages41
JournalAdvances in Biochemical Engineering/Biotechnology
Volume112
DOIs
StatePublished - 2009
Externally publishedYes

Keywords

  • Force production
  • Muscle development
  • Organ culture
  • Tissue culture

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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