Abstract
Molecular modeling of cyanoacrylates(cyanoacrylamides) with D1 protein of Pisum sativum have been presented. Studies show that the binding force includes mainly: H-bond interaction, Van der Waals and π-ring stacking interaction. It was found that SER 268 in D1 protein might be an important binding site. Thus some new cyanoacrylates (cyanoacrylamides) were designed and synthesized. For rapid optimization, combinatorial methods were introduced to synthesize 3-N-substituted (2-thio)hydrouracils library by the acidic cyclization-cleavage of ureas and thioureas from Wang resin. Their Hill inhibition is discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 226-235 |
| Number of pages | 10 |
| Journal | ACS Symposium Series |
| Volume | 774 |
| State | Published - 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Chemistry(all)
Cite this
Biorational design, synthesis, and inhibition of photosystem II inhibitors. / Liu, Huayin; Sha, Yinlin; Yu, Aiming; Tan, Huifen; Yang, Huazheng.
In: ACS Symposium Series, Vol. 774, 2001, p. 226-235.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biorational design, synthesis, and inhibition of photosystem II inhibitors
AU - Liu, Huayin
AU - Sha, Yinlin
AU - Yu, Aiming
AU - Tan, Huifen
AU - Yang, Huazheng
PY - 2001
Y1 - 2001
N2 - Molecular modeling of cyanoacrylates(cyanoacrylamides) with D1 protein of Pisum sativum have been presented. Studies show that the binding force includes mainly: H-bond interaction, Van der Waals and π-ring stacking interaction. It was found that SER 268 in D1 protein might be an important binding site. Thus some new cyanoacrylates (cyanoacrylamides) were designed and synthesized. For rapid optimization, combinatorial methods were introduced to synthesize 3-N-substituted (2-thio)hydrouracils library by the acidic cyclization-cleavage of ureas and thioureas from Wang resin. Their Hill inhibition is discussed.
AB - Molecular modeling of cyanoacrylates(cyanoacrylamides) with D1 protein of Pisum sativum have been presented. Studies show that the binding force includes mainly: H-bond interaction, Van der Waals and π-ring stacking interaction. It was found that SER 268 in D1 protein might be an important binding site. Thus some new cyanoacrylates (cyanoacrylamides) were designed and synthesized. For rapid optimization, combinatorial methods were introduced to synthesize 3-N-substituted (2-thio)hydrouracils library by the acidic cyclization-cleavage of ureas and thioureas from Wang resin. Their Hill inhibition is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0042850808&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042850808&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0042850808
VL - 774
SP - 226
EP - 235
JO - ACS Symposium Series
JF - ACS Symposium Series
SN - 0097-6156
ER -