Biopsy of an intracardiac paraganglioma in a dog using a fluoroscopically guided endovascular technique

Joseph S. Raleigh, William T.N. Culp, Rachel Brady, Sami Al-Nadaf, Michael S. Kent, Joanna L. Kaplan, Joshua A. Stern, Lance C. Visser, Kevin D. Niedringhaus, Tatiana G. Wolf, Eunju Choi, Verena K Affolter

Research output: Contribution to journalArticlepeer-review


A 10-year-old female spayed mixed breed dog was evaluated for diarrhea and vomiting. Diagnostic imaging demonstrated the presence of an intracardiac mass. A modified Seldinger technique was used to access the right jugular vein, and an endomyocardial biopsy forceps was introduced through a sheath to obtain several biopsies. Histopathology and immunohistochemistry demonstrated a paraganglioma. The dog underwent 1 fraction of radiotherapy and l-asparaginase chemotherapy and was discharged. The dog developed a pulmonary thromboembolism 2 days after radiotherapy and chemotherapy, and the owner elected humane euthanasia. Although long-term assessment of treatment response was unable to be performed, this novel diagnostic option could be considered for similar cases due to success in obtaining a histopathologic diagnosis, which is essential in developing a disease-specific treatment plan. This report also describes the use of radiotherapy for primary treatment of an intracardiac neoplasm, which can be a consideration in the future.

Original languageEnglish (US)
JournalJournal of Veterinary Internal Medicine
StateAccepted/In press - 2021


  • atrium
  • cardiac
  • chromaffin
  • endomyocardial
  • neoplasia
  • reproductive tract
  • surgery
  • theriogenology

ASJC Scopus subject areas

  • veterinary(all)


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