Biophysics of cadherin-mediated cell-cell adhesion

S. Yamada, A. Cheung, T. N. Nguyen, W. Shih

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cadherin-mediated cell-cell adhesion is a key mechanical integrator of multicellular structure and movement. The cadherin junctions are under constant mechanical load whenever cell-to-cell interactions require remodeling, a common occurrence during embryogenesis, tissue repair and cancer cell invasion. Rapid adaptation of adhesive strength is regulated by the actin cytoskeleton, yet the precise mechanisms remain ambiguous. Diverse experimental approaches including genetic, biochemical and biophysical analyses are being used to decipher the molecular interactions at the cadherin-actin linkage, which are now shaping the modern view of cadherin junctions as mechanosensing complexes.

Original languageEnglish (US)
Title of host publicationComprehensive Biophysics
PublisherElsevier Inc.
Pages33-47
Number of pages15
Volume7
ISBN (Print)9780080957180
DOIs
StatePublished - 2012

Keywords

  • Actin cytoskeleton
  • Apical constriction
  • Cadherin
  • Catenin
  • Cell migration
  • Cell sorting
  • Cell-cell adhesion
  • Embryogenesis
  • Myosin II
  • Retrograde flow
  • Traction force
  • Wound healing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Yamada, S., Cheung, A., Nguyen, T. N., & Shih, W. (2012). Biophysics of cadherin-mediated cell-cell adhesion. In Comprehensive Biophysics (Vol. 7, pp. 33-47). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-374920-8.00704-9