Abstract
Cadherin-mediated cell-cell adhesion is a key mechanical integrator of multicellular structure and movement. The cadherin junctions are under constant mechanical load whenever cell-to-cell interactions require remodeling, a common occurrence during embryogenesis, tissue repair and cancer cell invasion. Rapid adaptation of adhesive strength is regulated by the actin cytoskeleton, yet the precise mechanisms remain ambiguous. Diverse experimental approaches including genetic, biochemical and biophysical analyses are being used to decipher the molecular interactions at the cadherin-actin linkage, which are now shaping the modern view of cadherin junctions as mechanosensing complexes.
| Original language | English (US) |
|---|---|
| Title of host publication | Comprehensive Biophysics |
| Publisher | Elsevier Inc. |
| Pages | 33-47 |
| Number of pages | 15 |
| Volume | 7 |
| ISBN (Print) | 9780080957180 |
| DOIs | |
| State | Published - 2012 |
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Keywords
- Actin cytoskeleton
- Apical constriction
- Cadherin
- Catenin
- Cell migration
- Cell sorting
- Cell-cell adhesion
- Embryogenesis
- Myosin II
- Retrograde flow
- Traction force
- Wound healing
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Biophysics of cadherin-mediated cell-cell adhesion. / Yamada, S.; Cheung, A.; Nguyen, T. N.; Shih, W.
Comprehensive Biophysics. Vol. 7 Elsevier Inc., 2012. p. 33-47.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Biophysics of cadherin-mediated cell-cell adhesion
AU - Yamada, S.
AU - Cheung, A.
AU - Nguyen, T. N.
AU - Shih, W.
PY - 2012
Y1 - 2012
N2 - Cadherin-mediated cell-cell adhesion is a key mechanical integrator of multicellular structure and movement. The cadherin junctions are under constant mechanical load whenever cell-to-cell interactions require remodeling, a common occurrence during embryogenesis, tissue repair and cancer cell invasion. Rapid adaptation of adhesive strength is regulated by the actin cytoskeleton, yet the precise mechanisms remain ambiguous. Diverse experimental approaches including genetic, biochemical and biophysical analyses are being used to decipher the molecular interactions at the cadherin-actin linkage, which are now shaping the modern view of cadherin junctions as mechanosensing complexes.
AB - Cadherin-mediated cell-cell adhesion is a key mechanical integrator of multicellular structure and movement. The cadherin junctions are under constant mechanical load whenever cell-to-cell interactions require remodeling, a common occurrence during embryogenesis, tissue repair and cancer cell invasion. Rapid adaptation of adhesive strength is regulated by the actin cytoskeleton, yet the precise mechanisms remain ambiguous. Diverse experimental approaches including genetic, biochemical and biophysical analyses are being used to decipher the molecular interactions at the cadherin-actin linkage, which are now shaping the modern view of cadherin junctions as mechanosensing complexes.
KW - Actin cytoskeleton
KW - Apical constriction
KW - Cadherin
KW - Catenin
KW - Cell migration
KW - Cell sorting
KW - Cell-cell adhesion
KW - Embryogenesis
KW - Myosin II
KW - Retrograde flow
KW - Traction force
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84882795336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84882795336&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-374920-8.00704-9
DO - 10.1016/B978-0-12-374920-8.00704-9
M3 - Chapter
SN - 9780080957180
VL - 7
SP - 33
EP - 47
BT - Comprehensive Biophysics
PB - Elsevier Inc.
ER -