Biophysics in reverse: Using blood cells to accurately calibrate force-microscopy cantilevers

Volkmar Heinrich, Chawin Ounkomol

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

We report on the refinement and validation of one of the earliest ideas of "reverse" biophysics: the use of individual red blood cells as reliable, ultrasensitive mechanotransducers. Our analysis is based on the numerical prediction of the force exerted by a micropipette-held red cell as it is pushed against a test object. Examining this red-cell transducer, in conjunction with a custom-built "horizontal" force microscope, we were able to soundly corroborate its utility, while at the same time, accurately calibrating the spring constants of atomic-force microscope cantilevers.

Original languageEnglish (US)
Article number153902
JournalApplied Physics Letters
Volume92
Issue number15
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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