Abstract
We report on the refinement and validation of one of the earliest ideas of "reverse" biophysics: the use of individual red blood cells as reliable, ultrasensitive mechanotransducers. Our analysis is based on the numerical prediction of the force exerted by a micropipette-held red cell as it is pushed against a test object. Examining this red-cell transducer, in conjunction with a custom-built "horizontal" force microscope, we were able to soundly corroborate its utility, while at the same time, accurately calibrating the spring constants of atomic-force microscope cantilevers.
Original language | English (US) |
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Article number | 153902 |
Journal | Applied Physics Letters |
Volume | 92 |
Issue number | 15 |
DOIs | |
State | Published - 2008 |
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)