Abstract
We report on the refinement and validation of one of the earliest ideas of "reverse" biophysics: the use of individual red blood cells as reliable, ultrasensitive mechanotransducers. Our analysis is based on the numerical prediction of the force exerted by a micropipette-held red cell as it is pushed against a test object. Examining this red-cell transducer, in conjunction with a custom-built "horizontal" force microscope, we were able to soundly corroborate its utility, while at the same time, accurately calibrating the spring constants of atomic-force microscope cantilevers.
| Original language | English (US) |
|---|---|
| Article number | 153902 |
| Journal | Applied Physics Letters |
| Volume | 92 |
| Issue number | 15 |
| DOIs | |
| State | Published - 2008 |
ASJC Scopus subject areas
- Physics and Astronomy (miscellaneous)
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Cite this
Heinrich, V., & Ounkomol, C. (2008). Biophysics in reverse: Using blood cells to accurately calibrate force-microscopy cantilevers. Applied Physics Letters, 92(15), [153902]. https://doi.org/10.1063/1.2909529