Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots

Y. Sun; P. T. Vernier; Y. S. Liu; T. Black; C. H. Liang; S. Y. Chong; M. T. Chen; T. Tang; Laura Marcu; M. A. Gundersen

doi:10.1109/MODSYM.2006.365315

Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots

Y. Sun, P. T. Vernier, Y. S. Liu, T. Black, C. H. Liang, S. Y. Chong, M. T. Chen, T. Tang, Laura Marcu, M. A. Gundersen

Neurological Surgery

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We report the delivery of quantum dot (QD) fluorescence probes into mammalian cells by electroporation and endocytosis. The pH sensitivity of mercaptoacetic-acid-capped CdSe/ZnSe/ZnS quantum dots (MAA QDs) was investigated in both solution and living cells, demonstrating the potential of QDs as an intracellular pH sensor with long-term photostability and limited photobleaching. Further, QDs were utilized to enhance the effects of nanosecond electric pulses (nanoelectropulses) on malignant cells. Nanoelectropulse treatment is a developing technique for cancer therapy by inducing programmed cell death (apoptosis) of cancer cells, while the introduction of semiconductor particles could modify the electric characterization of biological cells.

Original language	English (US)
Title of host publication	Conference Record of the International Power Modulator Symposium and High Voltage Workshop
Pages	570-572
Number of pages	3
DOIs	https://doi.org/10.1109/MODSYM.2006.365315
State	Published - 2006
Event	2006 IEEE International Power Modulator Conference, IPMC(27th Power Modulator Symposium and 2006 High Voltage Workshop) - Washington, DC, United States Duration: May 14 2006 → May 18 2006

Other

Other	2006 IEEE International Power Modulator Conference, IPMC(27th Power Modulator Symposium and 2006 High Voltage Workshop)
Country/Territory	United States
City	Washington, DC
Period	5/14/06 → 5/18/06

ASJC Scopus subject areas

Engineering(all)

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10.1109/MODSYM.2006.365315

Cite this

Sun, Y., Vernier, P. T., Liu, Y. S., Black, T., Liang, C. H., Chong, S. Y., Chen, M. T., Tang, T., Marcu, L., & Gundersen, M. A. (2006). Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots. In Conference Record of the International Power Modulator Symposium and High Voltage Workshop (pp. 570-572). [4216267] https://doi.org/10.1109/MODSYM.2006.365315

Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots. / Sun, Y.; Vernier, P. T.; Liu, Y. S.; Black, T.; Liang, C. H.; Chong, S. Y.; Chen, M. T.; Tang, T.; Marcu, Laura; Gundersen, M. A.

Conference Record of the International Power Modulator Symposium and High Voltage Workshop. 2006. p. 570-572 4216267.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Sun, Y, Vernier, PT, Liu, YS, Black, T, Liang, CH, Chong, SY, Chen, MT, Tang, T, Marcu, L & Gundersen, MA 2006, Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots. in Conference Record of the International Power Modulator Symposium and High Voltage Workshop., 4216267, pp. 570-572, 2006 IEEE International Power Modulator Conference, IPMC(27th Power Modulator Symposium and 2006 High Voltage Workshop), Washington, DC, United States, 5/14/06. https://doi.org/10.1109/MODSYM.2006.365315

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title = "Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots",

abstract = "We report the delivery of quantum dot (QD) fluorescence probes into mammalian cells by electroporation and endocytosis. The pH sensitivity of mercaptoacetic-acid-capped CdSe/ZnSe/ZnS quantum dots (MAA QDs) was investigated in both solution and living cells, demonstrating the potential of QDs as an intracellular pH sensor with long-term photostability and limited photobleaching. Further, QDs were utilized to enhance the effects of nanosecond electric pulses (nanoelectropulses) on malignant cells. Nanoelectropulse treatment is a developing technique for cancer therapy by inducing programmed cell death (apoptosis) of cancer cells, while the introduction of semiconductor particles could modify the electric characterization of biological cells.",

author = "Y. Sun and Vernier, {P. T.} and Liu, {Y. S.} and T. Black and Liang, {C. H.} and Chong, {S. Y.} and Chen, {M. T.} and T. Tang and Laura Marcu and Gundersen, {M. A.}",

year = "2006",

doi = "10.1109/MODSYM.2006.365315",

language = "English (US)",

isbn = "142440018X",

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booktitle = "Conference Record of the International Power Modulator Symposium and High Voltage Workshop",

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AU - Sun, Y.

AU - Vernier, P. T.

AU - Liu, Y. S.

AU - Black, T.

AU - Liang, C. H.

AU - Chong, S. Y.

AU - Chen, M. T.

AU - Tang, T.

AU - Marcu, Laura

AU - Gundersen, M. A.

PY - 2006

Y1 - 2006

N2 - We report the delivery of quantum dot (QD) fluorescence probes into mammalian cells by electroporation and endocytosis. The pH sensitivity of mercaptoacetic-acid-capped CdSe/ZnSe/ZnS quantum dots (MAA QDs) was investigated in both solution and living cells, demonstrating the potential of QDs as an intracellular pH sensor with long-term photostability and limited photobleaching. Further, QDs were utilized to enhance the effects of nanosecond electric pulses (nanoelectropulses) on malignant cells. Nanoelectropulse treatment is a developing technique for cancer therapy by inducing programmed cell death (apoptosis) of cancer cells, while the introduction of semiconductor particles could modify the electric characterization of biological cells.

AB - We report the delivery of quantum dot (QD) fluorescence probes into mammalian cells by electroporation and endocytosis. The pH sensitivity of mercaptoacetic-acid-capped CdSe/ZnSe/ZnS quantum dots (MAA QDs) was investigated in both solution and living cells, demonstrating the potential of QDs as an intracellular pH sensor with long-term photostability and limited photobleaching. Further, QDs were utilized to enhance the effects of nanosecond electric pulses (nanoelectropulses) on malignant cells. Nanoelectropulse treatment is a developing technique for cancer therapy by inducing programmed cell death (apoptosis) of cancer cells, while the introduction of semiconductor particles could modify the electric characterization of biological cells.

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Y2 - 14 May 2006 through 18 May 2006

ER -

Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots

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