Biophotonic studies of mammalian cells with nanosecond pulsed power using quantum dots

Y. Sun, P. T. Vernier, Y. S. Liu, T. Black, C. H. Liang, S. Y. Chong, M. T. Chen, T. Tang, Laura Marcu, M. A. Gundersen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report the delivery of quantum dot (QD) fluorescence probes into mammalian cells by electroporation and endocytosis. The pH sensitivity of mercaptoacetic-acid-capped CdSe/ZnSe/ZnS quantum dots (MAA QDs) was investigated in both solution and living cells, demonstrating the potential of QDs as an intracellular pH sensor with long-term photostability and limited photobleaching. Further, QDs were utilized to enhance the effects of nanosecond electric pulses (nanoelectropulses) on malignant cells. Nanoelectropulse treatment is a developing technique for cancer therapy by inducing programmed cell death (apoptosis) of cancer cells, while the introduction of semiconductor particles could modify the electric characterization of biological cells.

Original languageEnglish (US)
Title of host publicationConference Record of the International Power Modulator Symposium and High Voltage Workshop
Pages570-572
Number of pages3
DOIs
StatePublished - 2006
Event2006 IEEE International Power Modulator Conference, IPMC(27th Power Modulator Symposium and 2006 High Voltage Workshop) - Washington, DC, United States
Duration: May 14 2006May 18 2006

Other

Other2006 IEEE International Power Modulator Conference, IPMC(27th Power Modulator Symposium and 2006 High Voltage Workshop)
CountryUnited States
CityWashington, DC
Period5/14/065/18/06

ASJC Scopus subject areas

  • Engineering(all)

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