Abstract
Regeneration is in part recapitulation of embryonic development and morphogenesis. Morphogenesis is the developmental cascade of pattern formation, body plan establishment and differentiation of tissues including bone and cartilage. Regenerative medicine is the science of design of tissues for functional restoration of damaged tissues. The three key elements of regenerative medicine are morphogens, stem cells and scaffolds of biomaterials. Biomaterials that mimic the tissue of interest will be most optimal for regeneration. Bone has considerable potential for regeneration. Yet, cartilage on adjacent tissue is feeble in the regenerative capacity. We have systematically investigated bone and cartilage regeneration with special focus on biomaterial properties including morphogens. Morphogens direct the lineage and final fate of responding stem cells. Morphogens include bone morphogenetic proteins (BMPs), hedgehogs, fibroblast growth factors (FGFs) and members of Wnts family. BMPs are the premier signals for bone and cartilage differentiation. The BMP family includes BMPs, cartilage derived morphogenetic proteins (BMPs) and growth/differentiation factors (GDFs). CDMPs 1-3 are also known as GDFs 5-7, and they play critical role in joint formation. Morphogens bind to biomaterials of the extracellular matrix such as collagens, proteoglycans and glycosaminoglycans. BMPs bind to collagens I and IV and heparin. BMPs bound to collagen is a bioactive biomaterial scaffold that can induce bone and cartilage. BMPs were purified from extracellular matrix of demineralized bone. The dissociative extraction and reconstitution of BMPs from collagens in 1981 established the basic concept of the biomimetic biomaterial scaffold and its role in regeneration and tissue engineering. The optimal scaffolds for bone regeneration are collagens and hydroxyapatite. The ideal scaffold for cartilage is materials with viscoelastic and hydrodynamic properties that mimic extracellular matrix of cartilage. The integration of morphogens in the optimal biomaterial scaffold to permit optimal rate of release is the key challenge for cartilage regeneration.
| Original language | English (US) |
|---|---|
| Title of host publication | Transactions - 7th World Biomaterials Congress |
| Pages | 199 |
| Number of pages | 1 |
| State | Published - 2004 |
| Event | Transactions - 7th World Biomaterials Congress - Sydney, Australia Duration: May 17 2004 → May 21 2004 |
Other
| Other | Transactions - 7th World Biomaterials Congress |
|---|---|
| Country | Australia |
| City | Sydney |
| Period | 5/17/04 → 5/21/04 |
Fingerprint
ASJC Scopus subject areas
- Engineering(all)
Cite this
Biomimetic biomaterial scaffolds for bone and cartilage regeneration. / Reddi, A Hari.
Transactions - 7th World Biomaterials Congress. 2004. p. 199.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Biomimetic biomaterial scaffolds for bone and cartilage regeneration
AU - Reddi, A Hari
PY - 2004
Y1 - 2004
N2 - Regeneration is in part recapitulation of embryonic development and morphogenesis. Morphogenesis is the developmental cascade of pattern formation, body plan establishment and differentiation of tissues including bone and cartilage. Regenerative medicine is the science of design of tissues for functional restoration of damaged tissues. The three key elements of regenerative medicine are morphogens, stem cells and scaffolds of biomaterials. Biomaterials that mimic the tissue of interest will be most optimal for regeneration. Bone has considerable potential for regeneration. Yet, cartilage on adjacent tissue is feeble in the regenerative capacity. We have systematically investigated bone and cartilage regeneration with special focus on biomaterial properties including morphogens. Morphogens direct the lineage and final fate of responding stem cells. Morphogens include bone morphogenetic proteins (BMPs), hedgehogs, fibroblast growth factors (FGFs) and members of Wnts family. BMPs are the premier signals for bone and cartilage differentiation. The BMP family includes BMPs, cartilage derived morphogenetic proteins (BMPs) and growth/differentiation factors (GDFs). CDMPs 1-3 are also known as GDFs 5-7, and they play critical role in joint formation. Morphogens bind to biomaterials of the extracellular matrix such as collagens, proteoglycans and glycosaminoglycans. BMPs bind to collagens I and IV and heparin. BMPs bound to collagen is a bioactive biomaterial scaffold that can induce bone and cartilage. BMPs were purified from extracellular matrix of demineralized bone. The dissociative extraction and reconstitution of BMPs from collagens in 1981 established the basic concept of the biomimetic biomaterial scaffold and its role in regeneration and tissue engineering. The optimal scaffolds for bone regeneration are collagens and hydroxyapatite. The ideal scaffold for cartilage is materials with viscoelastic and hydrodynamic properties that mimic extracellular matrix of cartilage. The integration of morphogens in the optimal biomaterial scaffold to permit optimal rate of release is the key challenge for cartilage regeneration.
AB - Regeneration is in part recapitulation of embryonic development and morphogenesis. Morphogenesis is the developmental cascade of pattern formation, body plan establishment and differentiation of tissues including bone and cartilage. Regenerative medicine is the science of design of tissues for functional restoration of damaged tissues. The three key elements of regenerative medicine are morphogens, stem cells and scaffolds of biomaterials. Biomaterials that mimic the tissue of interest will be most optimal for regeneration. Bone has considerable potential for regeneration. Yet, cartilage on adjacent tissue is feeble in the regenerative capacity. We have systematically investigated bone and cartilage regeneration with special focus on biomaterial properties including morphogens. Morphogens direct the lineage and final fate of responding stem cells. Morphogens include bone morphogenetic proteins (BMPs), hedgehogs, fibroblast growth factors (FGFs) and members of Wnts family. BMPs are the premier signals for bone and cartilage differentiation. The BMP family includes BMPs, cartilage derived morphogenetic proteins (BMPs) and growth/differentiation factors (GDFs). CDMPs 1-3 are also known as GDFs 5-7, and they play critical role in joint formation. Morphogens bind to biomaterials of the extracellular matrix such as collagens, proteoglycans and glycosaminoglycans. BMPs bind to collagens I and IV and heparin. BMPs bound to collagen is a bioactive biomaterial scaffold that can induce bone and cartilage. BMPs were purified from extracellular matrix of demineralized bone. The dissociative extraction and reconstitution of BMPs from collagens in 1981 established the basic concept of the biomimetic biomaterial scaffold and its role in regeneration and tissue engineering. The optimal scaffolds for bone regeneration are collagens and hydroxyapatite. The ideal scaffold for cartilage is materials with viscoelastic and hydrodynamic properties that mimic extracellular matrix of cartilage. The integration of morphogens in the optimal biomaterial scaffold to permit optimal rate of release is the key challenge for cartilage regeneration.
UR - http://www.scopus.com/inward/record.url?scp=13844272929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=13844272929&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:13844272929
SN - 1877040193
SN - 9781877040191
SP - 199
BT - Transactions - 7th World Biomaterials Congress
ER -