Biomaterial-guided gene delivery for musculoskeletal tissue repair

Justin L. Madrigal, Roberta Stilhano, Eduardo Silva

Research output: Contribution to journalReview article

10 Scopus citations

Abstract

Gene therapy is a promising strategy for musculoskeletal tissue repair and regeneration where local and sustained expression of proteins and/or therapeutic nucleic acids can be achieved. However, the musculoskeletal tissues present unique engineering and biological challenges as recipients of genetic vectors. Targeting specific cell populations, regulating expression in vivo, and overcoming the harsh environment of damaged tissue accompany the general concerns of safety and efficacy common to all applications of gene therapy. In this review, we will first summarize these challenges and then discuss how biomaterial carriers for genetic vectors can address these issues. Second, we will review how limitations specific to given vectors further motivate the utility of biomaterial carriers. Finally, we will discuss how these concepts have been combined with tissue engineering strategies and approaches to improve the delivery of these vectors for musculoskeletal tissue regeneration.

Original languageEnglish (US)
Pages (from-to)347-361
Number of pages15
JournalTissue Engineering - Part B: Reviews
Volume23
Issue number4
DOIs
StatePublished - Aug 1 2017

Keywords

  • biomaterials
  • controlled release
  • gene therapy
  • musculoskeletal

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering

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