Biomarkers of nutrition for development (BOND)-vitamin A review

Sherry A. Tanumihardjo, Robert M. Russell, Charles B. Stephensen, Bryan M. Gannon, Neal E. Craft, Marjorie J. Haskell, Georg Lietz, Kerry Schulze, Daniel J. Raiten

Research output: Contribution to journalArticle

83 Citations (Scopus)

Abstract

The Biomarkers of Nutrition for Development (BOND) project is designed to provide evidence-informed advice to anyonewith an interest in the role of nutrition in health. The BOND program provides information with regard to selection, use, and interpretation of biomarkers of nutrient exposure, status, function, and effect, which will be especially useful for readerswho want to assess nutrient status. To accomplish this objective, expert panels are recruited to evaluate the literature and to draft comprehensive reports on the current state of the art with regard to specific nutrient biology and available biomarkers for assessing nutritional status at the individual and population levels. Phase I of the BOND project includes the evaluation of biomarkers for 6 nutrients: iodine, folate, zinc, iron, vitamin A, and vitamin B-12. This review of vitamin A is the current article in this series. Although the vitamin was discovered >100 y ago, vitamin A status assessment is not trivial. Serum retinol concentrations are under homeostatic control due in part to vitamin A's use in the body for growth and cellular differentiation and because of its toxic properties at high concentrations. Furthermore, serum retinol concentrations are depressed during infection and inflammation because retinol-binding protein (RBP) is a negative acute-phase reactant, which makes status assessment challenging. Thus, this review describes the clinical and functional indicators related to eye health and biochemical biomarkers of vitamin A status (i.e., serumretinol, RBP, breast-milk retinol, dose-response tests, isotope dilution methodology, and serum retinyl esters). These biomarkers are then related to liver vitamin A concentrations, which are usually considered the gold standard for vitamin A status. With regard to biomarkers, future research questions and gaps in our current understanding as well as limitations of the methods are described.

Original languageEnglish (US)
Pages (from-to)1816S-1848S
JournalJournal of Nutrition
Volume146
Issue number9
DOIs
StatePublished - 2016
Externally publishedYes

Fingerprint

Vitamin A
Biomarkers
Food
Retinol-Binding Proteins
Vitamins
Serum
Acute-Phase Proteins
Poisons
Health
Human Milk
Vitamin B 12
Nutritional Status
Folic Acid
Isotopes
Iodine
Zinc
Esters
Iron
Inflammation
Liver

Keywords

  • BOND
  • Breast milk
  • Dose response tests
  • Dried blood spot
  • Isotope dilution
  • Retinol-binding protein
  • Serum retinol
  • Vitamin A biomarkers
  • Vitamin A review
  • Xerophthalmia

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Tanumihardjo, S. A., Russell, R. M., Stephensen, C. B., Gannon, B. M., Craft, N. E., Haskell, M. J., ... Raiten, D. J. (2016). Biomarkers of nutrition for development (BOND)-vitamin A review. Journal of Nutrition, 146(9), 1816S-1848S. https://doi.org/10.3945/jn.115.229708

Biomarkers of nutrition for development (BOND)-vitamin A review. / Tanumihardjo, Sherry A.; Russell, Robert M.; Stephensen, Charles B.; Gannon, Bryan M.; Craft, Neal E.; Haskell, Marjorie J.; Lietz, Georg; Schulze, Kerry; Raiten, Daniel J.

In: Journal of Nutrition, Vol. 146, No. 9, 2016, p. 1816S-1848S.

Research output: Contribution to journalArticle

Tanumihardjo, SA, Russell, RM, Stephensen, CB, Gannon, BM, Craft, NE, Haskell, MJ, Lietz, G, Schulze, K & Raiten, DJ 2016, 'Biomarkers of nutrition for development (BOND)-vitamin A review', Journal of Nutrition, vol. 146, no. 9, pp. 1816S-1848S. https://doi.org/10.3945/jn.115.229708
Tanumihardjo SA, Russell RM, Stephensen CB, Gannon BM, Craft NE, Haskell MJ et al. Biomarkers of nutrition for development (BOND)-vitamin A review. Journal of Nutrition. 2016;146(9):1816S-1848S. https://doi.org/10.3945/jn.115.229708
Tanumihardjo, Sherry A. ; Russell, Robert M. ; Stephensen, Charles B. ; Gannon, Bryan M. ; Craft, Neal E. ; Haskell, Marjorie J. ; Lietz, Georg ; Schulze, Kerry ; Raiten, Daniel J. / Biomarkers of nutrition for development (BOND)-vitamin A review. In: Journal of Nutrition. 2016 ; Vol. 146, No. 9. pp. 1816S-1848S.
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