Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers

Adetunji T. Toriola, Ting Yuan D Cheng, Marian L. Neuhouser, Mark H. Wener, Yingye Zheng, Elissa Brown, Joshua W. Miller, Xiaoling Song, Shirley A A Beresford, Marc J. Gunter, Marie A. Caudill, Cornelia M. Ulrich

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Abstract

Initial studies have investigated the association between inflammation and colorectal cancer (CRC) using C-reactive protein (CRP) as a proinflammatory biomarker and have noted inconsistent results among women. We here report the findings from a large prospective study with repeat measurements of CRP, as well as serum amyloid A (SAA), an additional biomarker of inflammation, and risk of CRC. In the Women's Health Initiative Observational Study, we examined associations of CRP and SAA with CRC using repeat assessments (baseline and 3-year follow-up) among 953 matched case-control pairs for CRP and 966 pairs for SAA. Multivariate-adjusted conditional-logistic regression models were used with two-sided tests of significance. Receiver operating characteristic (ROC) curve analysis assessed their utility as early detection markers. Colon cancer risk (odds ratio [OR] and 95% confidence intervals) among women in the highest quintiles of CRP or SAA compared to those in the lowest quintiles was OR colon/CRP = 1.37 (0.95-1.97, p-trend = 0.04) and OR colon/SAA = 1.26 (0.88-1.80, p-trend = 0.10), respectively. Women with elevated concentrations of both CRP and SAA had an increased risk of ORcolon = 1.50 (1.12-2.00, p-value = 0.006) compared to those with low concentrations. No positive associations were observed with rectal cancer and weaker associations for CRC overall. Temporal changes in biomarkers more than 3 years did not predict risk. The area under the 6-month ROC curve for CRP+SAA was 0.62 (95% confidence interval = 0.55-0.68). Elevated inflammatory biomarkers are associated with an increased risk of CRC, mainly colon cancer. Nevertheless, changes in the biomarkers over time do not suggest that they merit consideration as early detection markers for CRC.

Original languageEnglish (US)
Pages (from-to)2648-2658
Number of pages11
JournalInternational Journal of Cancer
Volume132
Issue number11
DOIs
StatePublished - Jun 1 2013

Fingerprint

Serum Amyloid A Protein
C-Reactive Protein
Colorectal Neoplasms
Biomarkers
Inflammation
Odds Ratio
Colonic Neoplasms
ROC Curve
Colon
Logistic Models
Confidence Intervals
Women's Health
Rectal Neoplasms
Observational Studies
Prospective Studies

Keywords

  • C-reactive protein (CRP)
  • colorectal cancer
  • early detection
  • serum amyloid A (SAA)
  • women

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Toriola, A. T., Cheng, T. Y. D., Neuhouser, M. L., Wener, M. H., Zheng, Y., Brown, E., ... Ulrich, C. M. (2013). Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. International Journal of Cancer, 132(11), 2648-2658. https://doi.org/10.1002/ijc.27942

Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. / Toriola, Adetunji T.; Cheng, Ting Yuan D; Neuhouser, Marian L.; Wener, Mark H.; Zheng, Yingye; Brown, Elissa; Miller, Joshua W.; Song, Xiaoling; Beresford, Shirley A A; Gunter, Marc J.; Caudill, Marie A.; Ulrich, Cornelia M.

In: International Journal of Cancer, Vol. 132, No. 11, 01.06.2013, p. 2648-2658.

Research output: Contribution to journalArticle

Toriola, AT, Cheng, TYD, Neuhouser, ML, Wener, MH, Zheng, Y, Brown, E, Miller, JW, Song, X, Beresford, SAA, Gunter, MJ, Caudill, MA & Ulrich, CM 2013, 'Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers', International Journal of Cancer, vol. 132, no. 11, pp. 2648-2658. https://doi.org/10.1002/ijc.27942
Toriola, Adetunji T. ; Cheng, Ting Yuan D ; Neuhouser, Marian L. ; Wener, Mark H. ; Zheng, Yingye ; Brown, Elissa ; Miller, Joshua W. ; Song, Xiaoling ; Beresford, Shirley A A ; Gunter, Marc J. ; Caudill, Marie A. ; Ulrich, Cornelia M. / Biomarkers of inflammation are associated with colorectal cancer risk in women but are not suitable as early detection markers. In: International Journal of Cancer. 2013 ; Vol. 132, No. 11. pp. 2648-2658.
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abstract = "Initial studies have investigated the association between inflammation and colorectal cancer (CRC) using C-reactive protein (CRP) as a proinflammatory biomarker and have noted inconsistent results among women. We here report the findings from a large prospective study with repeat measurements of CRP, as well as serum amyloid A (SAA), an additional biomarker of inflammation, and risk of CRC. In the Women's Health Initiative Observational Study, we examined associations of CRP and SAA with CRC using repeat assessments (baseline and 3-year follow-up) among 953 matched case-control pairs for CRP and 966 pairs for SAA. Multivariate-adjusted conditional-logistic regression models were used with two-sided tests of significance. Receiver operating characteristic (ROC) curve analysis assessed their utility as early detection markers. Colon cancer risk (odds ratio [OR] and 95{\%} confidence intervals) among women in the highest quintiles of CRP or SAA compared to those in the lowest quintiles was OR colon/CRP = 1.37 (0.95-1.97, p-trend = 0.04) and OR colon/SAA = 1.26 (0.88-1.80, p-trend = 0.10), respectively. Women with elevated concentrations of both CRP and SAA had an increased risk of ORcolon = 1.50 (1.12-2.00, p-value = 0.006) compared to those with low concentrations. No positive associations were observed with rectal cancer and weaker associations for CRC overall. Temporal changes in biomarkers more than 3 years did not predict risk. The area under the 6-month ROC curve for CRP+SAA was 0.62 (95{\%} confidence interval = 0.55-0.68). Elevated inflammatory biomarkers are associated with an increased risk of CRC, mainly colon cancer. Nevertheless, changes in the biomarkers over time do not suggest that they merit consideration as early detection markers for CRC.",
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