Biomarkers of cancer-associated thromboembolism

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Venous thromboembolism is known to be associated with an increase in morbidity and mortality in patients with malignancy. Predictive laboratory biomarkers of venous thromboembolism (VTE) have long been sought after to improve outcomes and help guide clinical decision making. Previously studied biomarkers include C reactive protein (CRP), tissue factor expressing microparticles (TF MP), D-dimer, soluble P-selectin (sP-selectin), plasminogen activator inhibitor 1 (PAI-1), factor VIII, platelet count, and leukocyte counts. This chapter will focus on these possible biomarkers for cancer-associated thrombosis (CAT) with particular emphasis on the pathophysiology behind thrombosis formation as well as data from clinical studies in patients with malignancy. The incorporation of the above biomarkers into risk assessment tools to predict CAT will also be reviewed, as will risk factors for recurrent VTE in patients with malignancy. Further studies are ongoing to develop readily available biomarkers that can be incorporated into future risk assessment models with the goal of reducing morbidity and mortality due to cancer-associated thrombosis.

Original languageEnglish (US)
Title of host publicationCancer Treatment and Research
PublisherSpringer International Publishing
Pages69-85
Number of pages17
DOIs
StatePublished - Jan 1 2019

Publication series

NameCancer Treatment and Research
Volume179
ISSN (Print)0927-3042

Keywords

  • Biomarkers
  • C reactive protein
  • D-dimer
  • Factor VIII
  • P-selectin
  • Tissue factor
  • Venous thrombosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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