Biomarkers in IgA nephropathy

Vicki J. Hwang, Arzu Ulu, Justin Van Hoorebeke, Robert H Weiss

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

IgA nephropathy is the most common primary glomerulonephritis and presents with gross hematuria and upper respiratory infection, with slow progression to end-stage renal disease in up to 50% of affected patients. Kidney biopsies are the gold standard method of diagnosis and frequently are not performed as the majority of individuals are asymptomatic. Thus, there is a need to discover and validate prognostic and predictive biomarkers that can be noninvasively obtained and are specific to this disease. Here we discuss the current state of research in this area and examine validated and clinically promising biofluid and tissue biomarkers of IgA nephropathy.

Original languageEnglish (US)
Pages (from-to)1263-1277
Number of pages15
JournalBiomarkers in Medicine
Volume8
Issue number10
DOIs
StatePublished - Dec 1 2014

Keywords

  • biofluid
  • glomerulonephritis
  • glycomics
  • IgA nephropathy
  • predictive biomarker
  • prognostic biomarker
  • tissue

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical
  • Drug Discovery

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    Hwang, V. J., Ulu, A., Van Hoorebeke, J., & Weiss, R. H. (2014). Biomarkers in IgA nephropathy. Biomarkers in Medicine, 8(10), 1263-1277. https://doi.org/10.2217/bmm.14.92