Biomarkers in Acute Kidney Injury

Ling-Xin Chen; Jay L. Koyner

doi:10.1016/j.ccc.2015.06.002

Biomarkers in Acute Kidney Injury

Ling-Xin Chen, Jay L. Koyner

Research output: Contribution to journal › Review article › peer-review

20 Scopus citations

Abstract

Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.

Original language	English (US)
Pages (from-to)	633-648
Number of pages	16
Journal	Critical Care Clinics
Volume	31
Issue number	4
DOIs	https://doi.org/10.1016/j.ccc.2015.06.002
State	Published - Oct 1 2015
Externally published	Yes

Keywords

Acute kidney injury
Biomarkers
Mortality
Renal replacement therapy

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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10.1016/j.ccc.2015.06.002

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AB - Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.

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KW - Mortality

KW - Renal replacement therapy

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