Biomarkers in Acute Kidney Injury

Ling-Xin Chen, Jay L. Koyner

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.

Original languageEnglish (US)
Pages (from-to)633-648
Number of pages16
JournalCritical Care Clinics
Issue number4
StatePublished - Oct 1 2015
Externally publishedYes


  • Acute kidney injury
  • Biomarkers
  • Mortality
  • Renal replacement therapy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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