Abstract
Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 633-648 |
| Number of pages | 16 |
| Journal | Critical Care Clinics |
| Volume | 31 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1 2015 |
| Externally published | Yes |
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Keywords
- Acute kidney injury
- Biomarkers
- Mortality
- Renal replacement therapy
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
Cite this
Biomarkers in Acute Kidney Injury. / Chen, Ling-Xin; Koyner, Jay L.
In: Critical Care Clinics, Vol. 31, No. 4, 01.10.2015, p. 633-648.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Biomarkers in Acute Kidney Injury
AU - Chen, Ling-Xin
AU - Koyner, Jay L.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.
AB - Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.
KW - Acute kidney injury
KW - Biomarkers
KW - Mortality
KW - Renal replacement therapy
UR - http://www.scopus.com/inward/record.url?scp=84942193948&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84942193948&partnerID=8YFLogxK
U2 - 10.1016/j.ccc.2015.06.002
DO - 10.1016/j.ccc.2015.06.002
M3 - Review article
C2 - 26410134
AN - SCOPUS:84942193948
VL - 31
SP - 633
EP - 648
JO - Critical Care Clinics
JF - Critical Care Clinics
SN - 0749-0704
IS - 4
ER -