Biomarkers in Acute Kidney Injury

Ling-Xin Chen, Jay L. Koyner

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.

Original languageEnglish (US)
Pages (from-to)633-648
Number of pages16
JournalCritical Care Clinics
Volume31
Issue number4
DOIs
StatePublished - Oct 1 2015
Externally publishedYes

Fingerprint

Acute Kidney Injury
Biomarkers
Kidney
Morbidity
Wounds and Injuries

Keywords

  • Acute kidney injury
  • Biomarkers
  • Mortality
  • Renal replacement therapy

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Biomarkers in Acute Kidney Injury. / Chen, Ling-Xin; Koyner, Jay L.

In: Critical Care Clinics, Vol. 31, No. 4, 01.10.2015, p. 633-648.

Research output: Contribution to journalReview article

Chen, Ling-Xin ; Koyner, Jay L. / Biomarkers in Acute Kidney Injury. In: Critical Care Clinics. 2015 ; Vol. 31, No. 4. pp. 633-648.
@article{b652b0448d7d451da26d9edd89e3f4fe,
title = "Biomarkers in Acute Kidney Injury",
abstract = "Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.",
keywords = "Acute kidney injury, Biomarkers, Mortality, Renal replacement therapy",
author = "Ling-Xin Chen and Koyner, {Jay L.}",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.ccc.2015.06.002",
language = "English (US)",
volume = "31",
pages = "633--648",
journal = "Critical Care Clinics",
issn = "0749-0704",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Biomarkers in Acute Kidney Injury

AU - Chen, Ling-Xin

AU - Koyner, Jay L.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.

AB - Acute kidney injury (AKI) is a common and often lethal complication that is also associated with severe morbidity in hospitalized patients. During the last decade, the standardization of AKI diagnostic criteria has helped to facilitate several large-scale investigations of biomarkers of AKI. These studies have led to the international clinical implementation of several biomarkers of renal injury. This review summarizes the results of many of these multicenter investigations and discusses the clinical utility and interpretation of several of these new clinical tests. The merits of combining biomarkers of kidney function is also discussed.

KW - Acute kidney injury

KW - Biomarkers

KW - Mortality

KW - Renal replacement therapy

UR - http://www.scopus.com/inward/record.url?scp=84942193948&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84942193948&partnerID=8YFLogxK

U2 - 10.1016/j.ccc.2015.06.002

DO - 10.1016/j.ccc.2015.06.002

M3 - Review article

C2 - 26410134

AN - SCOPUS:84942193948

VL - 31

SP - 633

EP - 648

JO - Critical Care Clinics

JF - Critical Care Clinics

SN - 0749-0704

IS - 4

ER -