Abstract
The 1990s were marked by tremendous progress in understanding HIV-1 infection and disease progression in infected individuals. The new discoveries had direct applications in predicting clinical outcomes and monitoring antiviral therapies. With the identification of secondary receptors of HIV-1 cell entry, the CCR-5 receptor was found to be a single genetically determined factor that influences both HIV-1 transmission and disease progression. Quantitation of HIV-1 RNA led to the discoveries that detectable or even high levels of HIV-1 replication occur during all phases of infection and that plasma HIV-1 RNA levels are powerful predictors of clinical outcome. These discoveries in pathogenesis have already been adopted as standards to predict disease progression and to monitor antiviral therapy in infected individuals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 731-742 |
| Number of pages | 12 |
| Journal | Obstetrics and Gynecology Clinics of North America |
| Volume | 24 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1997 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
Cite this
Biology of HIV-1 in women and men. / Burger, Harold; Weiser, Barbara.
In: Obstetrics and Gynecology Clinics of North America, Vol. 24, No. 4, 1997, p. 731-742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biology of HIV-1 in women and men
AU - Burger, Harold
AU - Weiser, Barbara
PY - 1997
Y1 - 1997
N2 - The 1990s were marked by tremendous progress in understanding HIV-1 infection and disease progression in infected individuals. The new discoveries had direct applications in predicting clinical outcomes and monitoring antiviral therapies. With the identification of secondary receptors of HIV-1 cell entry, the CCR-5 receptor was found to be a single genetically determined factor that influences both HIV-1 transmission and disease progression. Quantitation of HIV-1 RNA led to the discoveries that detectable or even high levels of HIV-1 replication occur during all phases of infection and that plasma HIV-1 RNA levels are powerful predictors of clinical outcome. These discoveries in pathogenesis have already been adopted as standards to predict disease progression and to monitor antiviral therapy in infected individuals.
AB - The 1990s were marked by tremendous progress in understanding HIV-1 infection and disease progression in infected individuals. The new discoveries had direct applications in predicting clinical outcomes and monitoring antiviral therapies. With the identification of secondary receptors of HIV-1 cell entry, the CCR-5 receptor was found to be a single genetically determined factor that influences both HIV-1 transmission and disease progression. Quantitation of HIV-1 RNA led to the discoveries that detectable or even high levels of HIV-1 replication occur during all phases of infection and that plasma HIV-1 RNA levels are powerful predictors of clinical outcome. These discoveries in pathogenesis have already been adopted as standards to predict disease progression and to monitor antiviral therapy in infected individuals.
UR - http://www.scopus.com/inward/record.url?scp=0031451724&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031451724&partnerID=8YFLogxK
U2 - 10.1016/S0889-8545(05)70341-7
DO - 10.1016/S0889-8545(05)70341-7
M3 - Article
VL - 24
SP - 731
EP - 742
JO - Obstetrics and Gynecology Clinics of North America
JF - Obstetrics and Gynecology Clinics of North America
SN - 0889-8545
IS - 4
ER -