Biology of HIV-1 in women and men

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The 1990s were marked by tremendous progress in understanding HIV-1 infection and disease progression in infected individuals. The new discoveries had direct applications in predicting clinical outcomes and monitoring antiviral therapies. With the identification of secondary receptors of HIV-1 cell entry, the CCR-5 receptor was found to be a single genetically determined factor that influences both HIV-1 transmission and disease progression. Quantitation of HIV-1 RNA led to the discoveries that detectable or even high levels of HIV-1 replication occur during all phases of infection and that plasma HIV-1 RNA levels are powerful predictors of clinical outcome. These discoveries in pathogenesis have already been adopted as standards to predict disease progression and to monitor antiviral therapy in infected individuals.

Original languageEnglish (US)
Pages (from-to)731-742
Number of pages12
JournalObstetrics and Gynecology Clinics of North America
Issue number4
StatePublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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