Biologics: Target-specific treatment of systemic and cutaneous autoimmune diseases

Siba P Raychaudhuri, Smriti Raychaudhuri

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

Biologics are becoming important in the treatment of systemic and cutaneous autoimmune diseases. They are designed to target specific components of immune system. As the new drugs are capable of targeting proteins in a more specific fashion, yet have lower risks of systemic side-effects, they have considerable advantages over the older immunomodulators. The development of TNF-alpha blockers in the treatment of psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease and ankylosing spondylitis have been major breakthroughs. Likewise, B-cell depletion has proved to be equally revolutionary for the treatment of lupus, pemphigus, certain vasculitides etc. But all said and done, the development of these molecules and their clinical usage are still at evolving stages. Consensus needs be formed to further categorize the clinical profiles of the patients in whom biologics are to be used in the future, given that the long-term safety profiles of these agents are very much unknown at present.

Original languageEnglish (US)
Pages (from-to)100-109
Number of pages10
JournalIndian Journal of Dermatology
Volume54
Issue number2
DOIs
StatePublished - Apr 1 2009

Keywords

  • Anti-cytokines
  • B-Lymphocyte
  • Biologics
  • Immunonodulation
  • TCR

ASJC Scopus subject areas

  • Dermatology

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