TY - JOUR
T1 - Biological therapy of psoriasis
AU - Sivamani, Raja K
AU - Correa, Genevieve
AU - Ono, Yoko
AU - Bowen, Michael P.
AU - Raychaudhuri, Siba P
AU - Maverakis, Emanual Michael
PY - 2010/4/1
Y1 - 2010/4/1
N2 - The treatment of psoriasis has undergone a revolution with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These medications are designed to target specific components of the immune system and are a major technological advancement over traditional immunosuppressive medications. These usually being well tolerated are being found useful in a growing number of immune-mediated diseases, psoriasis being just one example. The newest biologic, ustekinumab, is directed against the p40 subunit of the IL-12 and IL-23 cytokines. It has provided a new avenue of therapy for an array of T-cell-mediated diseases. Biologics are generally safe; however, there has been concern over the risk of lymphoma with use of these agents. All anti-TNF- agents have been associated with a variety of serious and "routine" opportunistic infections.
AB - The treatment of psoriasis has undergone a revolution with the advent of biologic therapies, including infliximab, etanercept, adalimumab, efalizumab, and alefacept. These medications are designed to target specific components of the immune system and are a major technological advancement over traditional immunosuppressive medications. These usually being well tolerated are being found useful in a growing number of immune-mediated diseases, psoriasis being just one example. The newest biologic, ustekinumab, is directed against the p40 subunit of the IL-12 and IL-23 cytokines. It has provided a new avenue of therapy for an array of T-cell-mediated diseases. Biologics are generally safe; however, there has been concern over the risk of lymphoma with use of these agents. All anti-TNF- agents have been associated with a variety of serious and "routine" opportunistic infections.
KW - Adverse effects
KW - Biologics
KW - Psoriasis
KW - Therapy
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U2 - 10.4103/0019-5154.62754
DO - 10.4103/0019-5154.62754
M3 - Article
C2 - 20606887
AN - SCOPUS:77952086525
VL - 55
SP - 161
EP - 170
JO - Indian Journal of Dermatology
JF - Indian Journal of Dermatology
SN - 0019-5154
IS - 2
ER -