TY - JOUR
T1 - Biological responses to physicochemical properties of biomaterial surface
AU - Rahmati, Maryam
AU - Silva, Eduardo A.
AU - Reseland, Janne E.
AU - A. Heyward, Catherine
AU - Haugen, Håvard J.
N1 - Funding Information:
Maryam Rahmati is a PhD Research Fellow in Tissue Regene- ration at University of Oslo. She is currently working on the corre- lation between recently developed chemical and biological imaging techniques for analyzing body responses to biomaterials. She is doing her PhD in Prof. Haugen’s research group and her projects are funded by European Training Network within the framework of Horizon2020 Marie Skłodowska- Curie Action (MSCA). She was awarded a master’s degree in biomaterials science from Materials and Energy Research Center, Tehran, Iran, 2016. She worked as a biomaterials and tissue engineer at Iran University of Medical Sciences, Tehran, Iran, 2016–2018.
Funding Information:
Professor Haugen is the leader of Biomaterials group, Faculty of Dentistry, University of Oslo. He received his master’s degree in chemical engineering from Imperial College, UK, in 2001, and his PhD in biomaterials from Technische Universität München, Germany, in 2004. He worked as a scientist at the Central Institute for Medical Engineering, Munich, Helmholtz Institute for Biomedical Engi- neering, Aachen and the Tissue Engineering Centre of Imperial College, London. Haugen has been awarded many research grants and innovation awards from both the European Research Council and the Research Council of Norway. Haugen was the past President of the Scandinavian Society for Biomaterials.
Funding Information:
This work was supported by a project ‘‘Promoting patient safety by a novel combination of imaging technologies for biodegradable magnesium implants, MgSafe’’ funded by European Training Network within the framework of Horizon2020 Marie Skłodowska-Curie Action (MSCA) grant number no. 811226 (www.mgsafe.eu). Eduardo A. Silva was supported by the American Heart Association grant # 19IPLOI34760654/Eduardo Silva/ 2019. We would like to thank Prof. Silvia M. Rogers, the head of MEDWRITE Company, Basel, Switzerland, who kindly helped us with her professional comments on the scientific writing part of this paper. We also thank Dr Matilde Bongio (www. matildebongio.com), who designed some informative illustrations for this paper.
PY - 2020/8/7
Y1 - 2020/8/7
N2 - Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is devoted to the design and validation of biomaterials, the nature of their interactions with the surrounding biological microenvironment is commonly neglected. This gap of knowledge could be owing to our poor understanding of biochemical signaling pathways, lack of reliable techniques for designing biomaterials with optimal physicochemical properties, and/or poor stability of biomaterial properties after implantation. The success of host responses to biomaterials, known as biocompatibility, depends on chemical principles as the root of both cell signaling pathways in the body and how the biomaterial surface is designed. Most of the current review papers have discussed chemical engineering and biological principles of designing biomaterials as separate topics, which has resulted in neglecting the main role of chemistry in this field. In this review, we discuss biocompatibility in the context of chemistry, what it is and how to assess it, while describing contributions from both biochemical cues and biomaterials as well as the means of harmonizing them. We address both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry. As we aim to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses, we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility complex. Finally, we discuss the progress and challenges associated with the current strategies used for improving the chemical and physical interactions between cells and biomaterial surface. This journal is
AB - Biomedical scientists use chemistry-driven processes found in nature as an inspiration to design biomaterials as promising diagnostic tools, therapeutic solutions, or tissue substitutes. While substantial consideration is devoted to the design and validation of biomaterials, the nature of their interactions with the surrounding biological microenvironment is commonly neglected. This gap of knowledge could be owing to our poor understanding of biochemical signaling pathways, lack of reliable techniques for designing biomaterials with optimal physicochemical properties, and/or poor stability of biomaterial properties after implantation. The success of host responses to biomaterials, known as biocompatibility, depends on chemical principles as the root of both cell signaling pathways in the body and how the biomaterial surface is designed. Most of the current review papers have discussed chemical engineering and biological principles of designing biomaterials as separate topics, which has resulted in neglecting the main role of chemistry in this field. In this review, we discuss biocompatibility in the context of chemistry, what it is and how to assess it, while describing contributions from both biochemical cues and biomaterials as well as the means of harmonizing them. We address both biochemical signal-transduction pathways and engineering principles of designing a biomaterial with an emphasis on its surface physicochemistry. As we aim to show the role of chemistry in the crosstalk between the surface physicochemical properties and body responses, we concisely highlight the main biochemical signal-transduction pathways involved in the biocompatibility complex. Finally, we discuss the progress and challenges associated with the current strategies used for improving the chemical and physical interactions between cells and biomaterial surface. This journal is
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U2 - 10.1039/d0cs00103a
DO - 10.1039/d0cs00103a
M3 - Review article
C2 - 32642749
AN - SCOPUS:85089124990
VL - 49
SP - 5178
EP - 5224
JO - Chemical Society Reviews
JF - Chemical Society Reviews
SN - 0306-0012
IS - 15
ER -