Biological NMR spectral analysis by an expert system

John L. Chow, Karl N. Levitt, Gerald J Kost

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

An expert system has been developed to facilitate biological 31-phosphorus nuclear magnetic resonance (31-PNMR) spectral analysis and interpretation. The expert system represents knowledge as production rules that reason about signal extraction, noise treatment, resonance assignment, intracellular pH determination, and metabolite intensity quantitation. The results from analysis of NMR spectra obtained from cardiovascular studies demonstrated that this artificial intelligence technique combined with statistical and numerical methods provides a framework for an efficient and reliable system for the analysis of complex, noisy biological 31-PNMR spectra.

Original languageEnglish (US)
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
Place of PublicationPiscataway, NJ, United States
PublisherPubl by IEEE
Pages1391-1392
Number of pages2
Volume10 pt 3
StatePublished - 1988
EventProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA
Duration: Nov 4 1988Nov 7 1988

Other

OtherProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityNew Orleans, LA, USA
Period11/4/8811/7/88

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Chow, J. L., Levitt, K. N., & Kost, G. J. (1988). Biological NMR spectral analysis by an expert system. In IEEE/Engineering in Medicine and Biology Society Annual Conference (Vol. 10 pt 3, pp. 1391-1392). Publ by IEEE.