Abstract
Ground squirrel hepatitis virus (GSHV) is a small DNA virus, structurally and antigenically related to the human hepatitis B virus, which occurs naturally among certain wild populations of ground squirrels (P.L. Marion et al., Proc. Natl. Acad. Sci. U.S.A. 77:2941-2945, 1980). Serum from naturally infected animals was used to transmit GSHV in the laboratory by parenteral inoculation of susceptible squirrels. Sixty percent of recipient animals developed viral surface antigenemia after a latent period of 2 to 3 months; three of these animals have remained viremic for over 9 months. Like hepatitis B virus, GSHV demonstrates marked hepatotropism, with viral DNA detected in significant quantities only in the liver, where an average of 6 x 102 to 6 x 103 viral DNA molecules per cell were found by molecular hybridization. However, histological signs of liver injury after acute infection are minimal. In contrast to infection of its natural host, parenteral administration of GSHV to rats, mice, guinea pigs, and hamsters did not result in demonstrable antigenemia, suggesting that the host range of GSHV, like that of hepatitis B virus, is narrow.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 366-373 |
| Number of pages | 8 |
| Journal | Journal of Virology |
| Volume | 44 |
| Issue number | 1 |
| State | Published - 1982 |
| Externally published | Yes |
Fingerprint
ASJC Scopus subject areas
- Immunology
Cite this
Biological characterization of acute infection with ground squirrel hepatitis virus. / Ganem, D.; Weiser, Barbara; Barchuk, A.; Brown, R. J.; Varmus, H. E.
In: Journal of Virology, Vol. 44, No. 1, 1982, p. 366-373.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biological characterization of acute infection with ground squirrel hepatitis virus
AU - Ganem, D.
AU - Weiser, Barbara
AU - Barchuk, A.
AU - Brown, R. J.
AU - Varmus, H. E.
PY - 1982
Y1 - 1982
N2 - Ground squirrel hepatitis virus (GSHV) is a small DNA virus, structurally and antigenically related to the human hepatitis B virus, which occurs naturally among certain wild populations of ground squirrels (P.L. Marion et al., Proc. Natl. Acad. Sci. U.S.A. 77:2941-2945, 1980). Serum from naturally infected animals was used to transmit GSHV in the laboratory by parenteral inoculation of susceptible squirrels. Sixty percent of recipient animals developed viral surface antigenemia after a latent period of 2 to 3 months; three of these animals have remained viremic for over 9 months. Like hepatitis B virus, GSHV demonstrates marked hepatotropism, with viral DNA detected in significant quantities only in the liver, where an average of 6 x 102 to 6 x 103 viral DNA molecules per cell were found by molecular hybridization. However, histological signs of liver injury after acute infection are minimal. In contrast to infection of its natural host, parenteral administration of GSHV to rats, mice, guinea pigs, and hamsters did not result in demonstrable antigenemia, suggesting that the host range of GSHV, like that of hepatitis B virus, is narrow.
AB - Ground squirrel hepatitis virus (GSHV) is a small DNA virus, structurally and antigenically related to the human hepatitis B virus, which occurs naturally among certain wild populations of ground squirrels (P.L. Marion et al., Proc. Natl. Acad. Sci. U.S.A. 77:2941-2945, 1980). Serum from naturally infected animals was used to transmit GSHV in the laboratory by parenteral inoculation of susceptible squirrels. Sixty percent of recipient animals developed viral surface antigenemia after a latent period of 2 to 3 months; three of these animals have remained viremic for over 9 months. Like hepatitis B virus, GSHV demonstrates marked hepatotropism, with viral DNA detected in significant quantities only in the liver, where an average of 6 x 102 to 6 x 103 viral DNA molecules per cell were found by molecular hybridization. However, histological signs of liver injury after acute infection are minimal. In contrast to infection of its natural host, parenteral administration of GSHV to rats, mice, guinea pigs, and hamsters did not result in demonstrable antigenemia, suggesting that the host range of GSHV, like that of hepatitis B virus, is narrow.
UR - http://www.scopus.com/inward/record.url?scp=0019966559&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019966559&partnerID=8YFLogxK
M3 - Article
C2 - 7143570
AN - SCOPUS:0019966559
VL - 44
SP - 366
EP - 373
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 1
ER -