Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)

V. J. Coyle, K. M. Rassnick, L. B. Borst, C. O. Rodriguez, N. C. Northrup, T. M. Fan, L. D. Garrett

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The purpose of this retrospective study was to describe the biological behaviour of canine mandibular osteosarcoma (OSA) and to examine factors for their impact on metastasis-free interval (MFI) and survival time (ST). Records from dogs treated with mandibulectomy for OSA (1999-2007) were reviewed. Archived tumour samples were evaluated for mitotic index (MI) and tumour grade. Fifty dogs were included, 21 received chemotherapy. Twenty-nine dogs (58%) developed metastatic disease. The median MFI was 627 days, and median ST was 525 days. In univariate analysis MI > 40 was prognostic for decreased MFI and ST. Grade also influenced MFI and ST, with 5/21 (24%) dogs with grade II/III tumours metastasis-free at one year versus 16/22 (72%) dogs with grade I tumours (P = 0.002); and 5/21 (24%) dogs with grade II/III tumours alive versus 17/22 (77%) dogs with grade I tumours (P = 0.001). In multivariate analysis, histological grade and adjuvant chemotherapy were prognostic for MFI and ST.

Original languageEnglish (US)
Pages (from-to)89-97
Number of pages9
JournalVeterinary and Comparative Oncology
Volume13
Issue number2
DOIs
StatePublished - Jun 1 2015

Fingerprint

osteosarcoma
Osteosarcoma
retrospective studies
Canidae
Retrospective Studies
metastasis
Dogs
Neoplasm Metastasis
dogs
neoplasms
Neoplasms
Mitotic Index
drug therapy
Adjuvant Chemotherapy
multivariate analysis
adjuvants
Multivariate Analysis
Drug Therapy

Keywords

  • Chemotherapy
  • Grade
  • Jaw
  • Mitotic index
  • Oral tumour

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Coyle, V. J., Rassnick, K. M., Borst, L. B., Rodriguez, C. O., Northrup, N. C., Fan, T. M., & Garrett, L. D. (2015). Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007). Veterinary and Comparative Oncology, 13(2), 89-97. https://doi.org/10.1111/vco.12020

Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007). / Coyle, V. J.; Rassnick, K. M.; Borst, L. B.; Rodriguez, C. O.; Northrup, N. C.; Fan, T. M.; Garrett, L. D.

In: Veterinary and Comparative Oncology, Vol. 13, No. 2, 01.06.2015, p. 89-97.

Research output: Contribution to journalArticle

Coyle, VJ, Rassnick, KM, Borst, LB, Rodriguez, CO, Northrup, NC, Fan, TM & Garrett, LD 2015, 'Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007)', Veterinary and Comparative Oncology, vol. 13, no. 2, pp. 89-97. https://doi.org/10.1111/vco.12020
Coyle, V. J. ; Rassnick, K. M. ; Borst, L. B. ; Rodriguez, C. O. ; Northrup, N. C. ; Fan, T. M. ; Garrett, L. D. / Biological behaviour of canine mandibular osteosarcoma. A retrospective study of 50 cases (1999-2007). In: Veterinary and Comparative Oncology. 2015 ; Vol. 13, No. 2. pp. 89-97.
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