Biological basis of hypoalbuminemia in ESRD

Research output: Contribution to journalArticle

157 Citations (Scopus)

Abstract

Hypoalbuminemia is associated with mortality in patients with end-stage renal disease (ESRD) maintained either on peritoneal dialysis (PD) or hemodialysis (HD). Serum albumin concentration is determined by its rate of synthesis, by the catabolic rate constant (the fraction of the vascular pool catabolized per unit time), by external losses, and by redistribution from the vascular to the extravascular space. Hypoalbuminemia in dialysis patients is primarily a consequence of reduced albumin synthesis rate in both HD and PD patients, and in the case of PD patents, of transperitoneal albumin losses as well. Continuous ambulatory peritoneal dialysis patients are able to increase albumin synthesis to replace losses. Thus, ESRD does not directly suppress albumin synthesis. The rate of albumin synthesis is inversely proportional to the serum concentration of one potential acute phase protein (α2 macroglobulin), and albumin concentration is inversely proportional to that of either C-reactive protein or serum amyloid A in both HD and PD patients. The cause of decreased albumin synthesis is primarily a response to inflammation (the acute phase response), although it is possible that inadequate nutrition may also contribute. The cause of the inflammatory response is not immediately evident. There is no evidence that shifts of albumin to the extravascular space or that dilution of the plasma by volume expansion plays any role in causing hypoalbuminemia in ESRD patients.

Original languageEnglish (US)
Pages (from-to)2368-2376
Number of pages9
JournalJournal of the American Society of Nephrology
Volume9
Issue number12
StatePublished - Dec 1998

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Hypoalbuminemia
Chronic Kidney Failure
Albumins
Peritoneal Dialysis
Renal Dialysis
Blood Vessels
Serum Amyloid A Protein
Macroglobulins
Acute-Phase Reaction
Patents
Continuous Ambulatory Peritoneal Dialysis
Acute-Phase Proteins
Plasma Volume
Serum Albumin
C-Reactive Protein
Dialysis
Inflammation
Mortality

ASJC Scopus subject areas

  • Nephrology

Cite this

Biological basis of hypoalbuminemia in ESRD. / Kaysen, George.

In: Journal of the American Society of Nephrology, Vol. 9, No. 12, 12.1998, p. 2368-2376.

Research output: Contribution to journalArticle

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