Biologic length scale topographic features modulate human corneal epithelial cell adhesion and migration

N. W. Karuri, S. J. Liliensiek, K. A. Diehl, J. D. Foley, G. A. Abrams, S. Campbell, P. F. Nealey, Christopher J Murphy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The modulation of corneal epithelial cell adhesion and migration by topographic features was discussed. Electron-beam lithography and reaction ion etching were used to pattern silicon wafers with grooves and ridges of nano and microscale dimensions ranging in pitch from 400-4000 nm. It was found that nanoscale sized features induced stronger cell-substrate adhesion as compared to planar and microscale surfaces. The results show that biologic length scale topography modulates cells behavior including morphology, adhesion and migration of corneal epithelial cells.

Original languageEnglish (US)
Title of host publicationTransactions - 7th World Biomaterials Congress
Pages115
Number of pages1
StatePublished - 2004
Externally publishedYes
EventTransactions - 7th World Biomaterials Congress - Sydney, Australia
Duration: May 17 2004May 21 2004

Other

OtherTransactions - 7th World Biomaterials Congress
CountryAustralia
CitySydney
Period5/17/045/21/04

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Karuri, N. W., Liliensiek, S. J., Diehl, K. A., Foley, J. D., Abrams, G. A., Campbell, S., Nealey, P. F., & Murphy, C. J. (2004). Biologic length scale topographic features modulate human corneal epithelial cell adhesion and migration. In Transactions - 7th World Biomaterials Congress (pp. 115)