Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: A veterinary society of surgical oncology retrospective study

James P. Farese, Jolle Kirpensteijn, Marja Kik, Nicholas J. Bacon, Suzanne Shelly Waltman, Bernard Seguin, Michael S Kent, Julius Liptak, Rod Straw, Myron N. Chang, Yang Jiang, Stephen J. Withrow

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Abstract

Objective To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. Study Design Case series. Animals Dogs (n=25) with appendicular chondrosarcoma. Methods Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. Results Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16;.33; and.31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. Conclusion Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. Clinical Relevance The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.

Original languageEnglish (US)
Pages (from-to)914-919
Number of pages6
JournalVeterinary Surgery
Volume38
Issue number8
DOIs
StatePublished - Dec 2009

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Chondrosarcoma
amputation
Amputation
retrospective studies
Canidae
Retrospective Studies
Dogs
dogs
prognosis
neoplasms
metastasis
Neoplasm Metastasis
Neoplasms
osteosarcoma
gender
Osteosarcoma
Combination Drug Therapy
Tumor Burden
limbs (animal)
Proportional Hazards Models

ASJC Scopus subject areas

  • veterinary(all)

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Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation : A veterinary society of surgical oncology retrospective study. / Farese, James P.; Kirpensteijn, Jolle; Kik, Marja; Bacon, Nicholas J.; Waltman, Suzanne Shelly; Seguin, Bernard; Kent, Michael S; Liptak, Julius; Straw, Rod; Chang, Myron N.; Jiang, Yang; Withrow, Stephen J.

In: Veterinary Surgery, Vol. 38, No. 8, 12.2009, p. 914-919.

Research output: Contribution to journalArticle

Farese, JP, Kirpensteijn, J, Kik, M, Bacon, NJ, Waltman, SS, Seguin, B, Kent, MS, Liptak, J, Straw, R, Chang, MN, Jiang, Y & Withrow, SJ 2009, 'Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation: A veterinary society of surgical oncology retrospective study', Veterinary Surgery, vol. 38, no. 8, pp. 914-919. https://doi.org/10.1111/j.1532-950X.2009.00606.x
Farese, James P. ; Kirpensteijn, Jolle ; Kik, Marja ; Bacon, Nicholas J. ; Waltman, Suzanne Shelly ; Seguin, Bernard ; Kent, Michael S ; Liptak, Julius ; Straw, Rod ; Chang, Myron N. ; Jiang, Yang ; Withrow, Stephen J. / Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation : A veterinary society of surgical oncology retrospective study. In: Veterinary Surgery. 2009 ; Vol. 38, No. 8. pp. 914-919.
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AU - Kik, Marja

AU - Bacon, Nicholas J.

AU - Waltman, Suzanne Shelly

AU - Seguin, Bernard

AU - Kent, Michael S

AU - Liptak, Julius

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AU - Chang, Myron N.

AU - Jiang, Yang

AU - Withrow, Stephen J.

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N2 - Objective To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. Study Design Case series. Animals Dogs (n=25) with appendicular chondrosarcoma. Methods Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. Results Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16;.33; and.31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. Conclusion Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. Clinical Relevance The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.

AB - Objective To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. Study Design Case series. Animals Dogs (n=25) with appendicular chondrosarcoma. Methods Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. Results Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16;.33; and.31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. Conclusion Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. Clinical Relevance The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.

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