Abstract
Objective To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. Study Design Case series. Animals Dogs (n=25) with appendicular chondrosarcoma. Methods Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. Results Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16;.33; and.31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. Conclusion Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. Clinical Relevance The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 914-919 |
| Number of pages | 6 |
| Journal | Veterinary Surgery |
| Volume | 38 |
| Issue number | 8 |
| DOIs | |
| State | Published - Dec 2009 |
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ASJC Scopus subject areas
- veterinary(all)
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Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation : A veterinary society of surgical oncology retrospective study. / Farese, James P.; Kirpensteijn, Jolle; Kik, Marja; Bacon, Nicholas J.; Waltman, Suzanne Shelly; Seguin, Bernard; Kent, Michael S; Liptak, Julius; Straw, Rod; Chang, Myron N.; Jiang, Yang; Withrow, Stephen J.
In: Veterinary Surgery, Vol. 38, No. 8, 12.2009, p. 914-919.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biologic behavior and clinical outcome of 25 dogs with canine appendicular chondrosarcoma treated by amputation
T2 - A veterinary society of surgical oncology retrospective study
AU - Farese, James P.
AU - Kirpensteijn, Jolle
AU - Kik, Marja
AU - Bacon, Nicholas J.
AU - Waltman, Suzanne Shelly
AU - Seguin, Bernard
AU - Kent, Michael S
AU - Liptak, Julius
AU - Straw, Rod
AU - Chang, Myron N.
AU - Jiang, Yang
AU - Withrow, Stephen J.
PY - 2009/12
Y1 - 2009/12
N2 - Objective To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. Study Design Case series. Animals Dogs (n=25) with appendicular chondrosarcoma. Methods Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. Results Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16;.33; and.31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. Conclusion Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. Clinical Relevance The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.
AB - Objective To characterize biologic behavior, clinical outcome, and effect of histologic grade on prognosis for dogs with appendicular chondrosarcoma treated by amputation alone. Study Design Case series. Animals Dogs (n=25) with appendicular chondrosarcoma. Methods Medical records were searched to identify dogs with appendicular chondrosarcoma treated by limb amputation alone. Information recorded included signalment, anatomic location, radiographic appearance, and development of metastasis. Histopathologic diagnosis was confirmed and graded (1, 2, or 3). Survival curves were generated by the Kaplan-Meier method and the association between covariates (gender, age, weight, and tumor grade) and survival were evaluated using the univariate proportional hazards model. Results Histopathology slides were available for 25 dogs. Rates of pulmonary metastasis were as follows: grade 1-0%, grade 2-31%, and grade 3-50%. Overall median survival time (MST) was 979 days. Age, weight, and sex were not significantly associated with survival (P=.16;.33; and.31, respectively). Survival was significantly associated with tumor grade (P=.008), with dogs with tumor grade of 1, 2, and 3 having MSTs of 6, 2.7, and 0.9 years, respectively. Conclusion Canine appendicular chondrosarcoma can be treated effectively with amputation alone. Low to intermediate grade chondrosarcoma has a good prognosis, whereas high-grade tumors appear to behave aggressively. Clinical Relevance The overall prognosis for appendicular chondrosarcoma is better than that of appendicular osteosarcoma treated by amputation alone or in combination with chemotherapy.
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UR - http://www.scopus.com/inward/citedby.url?scp=71949111258&partnerID=8YFLogxK
U2 - 10.1111/j.1532-950X.2009.00606.x
DO - 10.1111/j.1532-950X.2009.00606.x
M3 - Article
C2 - 20017847
AN - SCOPUS:71949111258
VL - 38
SP - 914
EP - 919
JO - Veterinary Surgery
JF - Veterinary Surgery
SN - 0161-3499
IS - 8
ER -