Bioengineering an artificial human blood–brain barrier in rodents

Kimia Kamal, Ben Waldau

Research output: Contribution to journalArticle

Abstract

Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling.

Original languageEnglish (US)
Article number38
JournalBioengineering
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2019

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Brain models
Endothelial cells
Brain
Rodentia
Bioengineering

Keywords

  • Blood
  • Brain barrier
  • Cerebrovascular disease
  • Immune system
  • NSG mouse
  • Organoid
  • Perfusion
  • Vascularization

ASJC Scopus subject areas

  • Bioengineering

Cite this

Bioengineering an artificial human blood–brain barrier in rodents. / Kamal, Kimia; Waldau, Ben.

In: Bioengineering, Vol. 6, No. 2, 38, 01.06.2019.

Research output: Contribution to journalArticle

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