Bioengineering an artificial human blood–brain barrier in rodents

Kimia Kamal, Ben Waldau

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling.

Original languageEnglish (US)
Article number38
Issue number2
StatePublished - Jun 1 2019


  • Blood
  • Brain barrier
  • Cerebrovascular disease
  • Immune system
  • NSG mouse
  • Organoid
  • Perfusion
  • Vascularization

ASJC Scopus subject areas

  • Bioengineering


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