Bioengineering an artificial human blood–brain barrier in rodents

Kimia Kamal, Ben Waldau

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Our group has recently created a novel in-vivo human brain organoid vascularized with human iPSC-derived endothelial cells. In this review article, we discuss the challenges of creating a perfused human brain organoid model in an immunosuppressed rodent host and discuss potential applications for neurosurgical disease modeling.

Original languageEnglish (US)
Article number38
JournalBioengineering
Volume6
Issue number2
DOIs
StatePublished - Jun 1 2019

Keywords

  • Blood
  • Brain barrier
  • Cerebrovascular disease
  • Immune system
  • NSG mouse
  • Organoid
  • Perfusion
  • Vascularization

ASJC Scopus subject areas

  • Bioengineering

Fingerprint Dive into the research topics of 'Bioengineering an artificial human blood–brain barrier in rodents'. Together they form a unique fingerprint.

  • Cite this