Bioengineered non-coding RNA agent (BERA) in action

Zhijian Duan, Aiming Yu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Non-coding RNAs (ncRNAs) including microRNAs (miRNAs) and small interfering RNAs (siRNAs) are important players in the control of gene regulation and represent novel promising therapeutic targets or agents for the treatment of various diseases. While synthetic ncRNAs are predominately utilized, the effects of excessive artificial modifications on higher-order structures, activities and toxicities of ncRNAs remain uncertain. Inspired by recombinant protein technology allowing large-scale bioengineering of proteins for research and therapy, efforts have been made to develop practical and effective means to bioengineer ncRNA agents. The fermentation-based approaches shall offer biological ncRNA agents with natural modifications and proper folding critical for ncRNA structure, function and safety. In this article, we will summarize current recombinant RNA platforms to the production of ncRNA agents including siRNAs and miRNAs. The applications of bioengineered ncRNA agents for basic research and potential therapeutics are also discussed.

Original languageEnglish (US)
Pages (from-to)1-7
Number of pages7
JournalBioengineered Bugs
DOIs
StateAccepted/In press - Aug 18 2016

Fingerprint

Untranslated RNA
RNA
MicroRNAs
Small Interfering RNA
Therapeutic Human Experimentation
Bioengineering
Biological Factors
Recombinant Proteins
Fermentation
Technology
Safety
Recombinant proteins
Gene expression
Toxicity
Therapeutics
Research
Genes
Proteins

Keywords

  • bioengineering
  • cancer
  • miRNA
  • non-coding RNAs
  • siRNA
  • therapy

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

Cite this

Bioengineered non-coding RNA agent (BERA) in action. / Duan, Zhijian; Yu, Aiming.

In: Bioengineered Bugs, 18.08.2016, p. 1-7.

Research output: Contribution to journalArticle

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