Bioelectronic silicon nanowire devices using functional membrane proteins

Nipun Misra, Julio A. Martinez, Shih Chieh J Huang, Yinmin Wang, Pieter Stroeve, Costas P. Grigoropoulos, Aleksandr Noy

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Modern means of communication rely on electric fields and currents to carry the flow of information. In contrast, biological systems follow a different paradigm that uses ion gradients and currents, flows of small molecules, and membrane electric potentials. Living organisms use a sophisticated arsenal of membrane receptors, channels, and pumps to control signal transduction to a degree that is unmatched by manmade devices. Electronic circuits that use such biological components could achieve drastically increased functionality; however, this approach requires nearly seamless integration of biological and manmade structures. We present a versatile hybrid platform for such integration that uses shielded nanowires (NWs) that are coated with a continuous lipid bilayer. We show that when shielded silicon NW transistors incorporate transmembrane peptide pores gramicidin A and alamethicin in the lipid bilayer they can achieve ionic to electronic signal transduction by using voltage-gated or chemically gated ion transport through the membrane pores.

Original languageEnglish (US)
Pages (from-to)13780-13784
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume106
Issue number33
DOIs
StatePublished - Aug 18 2009
Externally publishedYes

Fingerprint

Nanowires
Lipid Bilayers
Silicon
Signal Transduction
Membrane Proteins
Alamethicin
Gramicidin
Equipment and Supplies
Ion Transport
Ion Channels
Membrane Potentials
Ions
Peptides
Membranes

Keywords

  • Bionanoelectronics
  • Ion channels
  • Lipid bilayers
  • Membrane transport
  • Silicon nanowires

ASJC Scopus subject areas

  • General

Cite this

Bioelectronic silicon nanowire devices using functional membrane proteins. / Misra, Nipun; Martinez, Julio A.; Huang, Shih Chieh J; Wang, Yinmin; Stroeve, Pieter; Grigoropoulos, Costas P.; Noy, Aleksandr.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 33, 18.08.2009, p. 13780-13784.

Research output: Contribution to journalArticle

Misra, Nipun ; Martinez, Julio A. ; Huang, Shih Chieh J ; Wang, Yinmin ; Stroeve, Pieter ; Grigoropoulos, Costas P. ; Noy, Aleksandr. / Bioelectronic silicon nanowire devices using functional membrane proteins. In: Proceedings of the National Academy of Sciences of the United States of America. 2009 ; Vol. 106, No. 33. pp. 13780-13784.
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