TY - JOUR
T1 - Bioelectronic light-gated transistors with biologically tunable performance
AU - Tunuguntla, Ramya H.
AU - Bangar, Mangesh A.
AU - Kim, Kyunghoon
AU - Stroeve, Pieter
AU - Grigoropoulos, Costas
AU - Ajo-Franklin, Caroline M.
AU - Noy, Aleksandr
PY - 2015
Y1 - 2015
N2 - The use of a similar biological regulation mechanism in a light-powered bioelectronic device based on a 1D lipid bilayer device architecture. In these devices, a membrane protein resides within the lipid bilayer that covers a nanowire channel of a SiNW FET. The device platform was based on a microfabricated SiNW FET in which a single nanowire was clamped between a pair of source and drain electrodes insulated from the solution by a protective photoresist layer. Microfluidic channel filled with a buffer solution covered the active area of the chip. This configuration allowed fusing proteoliposomes onto the SiNW surface to create a continuous lipid bilayer that preserved the protein functionality. results show that ionophore molecules, coassembled with the membrane protein, upregulate and downregulate the device output by modulating the lipid membrane potential and altering the specific ion permeability of the membrane.
AB - The use of a similar biological regulation mechanism in a light-powered bioelectronic device based on a 1D lipid bilayer device architecture. In these devices, a membrane protein resides within the lipid bilayer that covers a nanowire channel of a SiNW FET. The device platform was based on a microfabricated SiNW FET in which a single nanowire was clamped between a pair of source and drain electrodes insulated from the solution by a protective photoresist layer. Microfluidic channel filled with a buffer solution covered the active area of the chip. This configuration allowed fusing proteoliposomes onto the SiNW surface to create a continuous lipid bilayer that preserved the protein functionality. results show that ionophore molecules, coassembled with the membrane protein, upregulate and downregulate the device output by modulating the lipid membrane potential and altering the specific ion permeability of the membrane.
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U2 - 10.1002/adma.201403988
DO - 10.1002/adma.201403988
M3 - Article
C2 - 25410490
AN - SCOPUS:84922127238
VL - 27
SP - 831
EP - 836
JO - Advanced Materials
JF - Advanced Materials
SN - 0935-9648
IS - 5
ER -