Biodegradable scaffolds for use in orthopaedic tissue engineering

Kyriacos Athanasiou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

A review of orthopaedic applications and biocompatibility studies of biodegradable polylactic acid, polyglycolic acid and their copolymers is presented. The experimental and clinical uses of polylactic acid-polyglycolic acid (PLA-PGA) polymers in the field of orthopaedics have seen significant growth recently, especially as fracture fixation devices and scaffolds for tissue ingrowth. Some complications have occasionally been reported following implantation of PLA-PGA biomaterials. Some of these problems may be attributable to biodegradation byproducts, which alter the pH of the environment. It is postulated that since the mechanical and other physical properties of these biomaterials can be appropriately designed within certain ranges, other aspects of orthopaedic medicine - such as soft tissue repair, synthetic grafts, and bone augmentation scaffolds - may be considered as candidates of PLA-PGA usage. To this end, the release of bioactive agents may be controlled and delivered in situ according to the needs of the repair tissues.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
Place of PublicationPiscataway, NJ, United States
PublisherIEEE
Pages541-544
Number of pages4
StatePublished - 1996
Externally publishedYes
EventProceedings of the 1996 15th Southern Biomedical Engineering Conference - Dayton, OH, USA
Duration: Mar 29 1996Mar 31 1996

Other

OtherProceedings of the 1996 15th Southern Biomedical Engineering Conference
CityDayton, OH, USA
Period3/29/963/31/96

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Athanasiou, K. (1996). Biodegradable scaffolds for use in orthopaedic tissue engineering. In Southern Biomedical Engineering Conference - Proceedings (pp. 541-544). IEEE.