Biochemical maturation of the non-innervated chick optic lobe

S. C. Bondy, K. C. Bonnet, M. E. Harrington, C. Z. Neurath, R. Nidess, A. Vernadakis, Philip R Vulliet, C. York

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The development of the chick optic lobe was impaired following removal of the optic cup of the early embryo. Tectal cell number is reduced but cell size may be relatively normal. There was evidence of neuronal cell death and several neuron-associated proteins and enzymes (nerve specific protein and acetylcholinesterase) showed selectively impaired maturation. However, other nerve specific enzymes (choline acetyltransferase, tyrosine hydroxylase), develop normally on a per cell basis. The noninnervated optic lobe had a normal blood brain barrier but a depressed ability to accumulate amino acids from plasma. Levels of 3':5'-cyclic GMP were also reduced in the nonafferented lobe.

Original languageEnglish (US)
Pages (from-to)54-61
Number of pages8
JournalDevelopmental Neuroscience
Volume1
Issue number1
StatePublished - 1978
Externally publishedYes

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Guanosine Monophosphate
Choline O-Acetyltransferase
Cyclic GMP
Tyrosine 3-Monooxygenase
Enzymes
Acetylcholinesterase
Blood-Brain Barrier
Cell Size
Proteins
Cell Death
Embryonic Structures
Cell Count
Neurons
Amino Acids

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Bondy, S. C., Bonnet, K. C., Harrington, M. E., Neurath, C. Z., Nidess, R., Vernadakis, A., ... York, C. (1978). Biochemical maturation of the non-innervated chick optic lobe. Developmental Neuroscience, 1(1), 54-61.

Biochemical maturation of the non-innervated chick optic lobe. / Bondy, S. C.; Bonnet, K. C.; Harrington, M. E.; Neurath, C. Z.; Nidess, R.; Vernadakis, A.; Vulliet, Philip R; York, C.

In: Developmental Neuroscience, Vol. 1, No. 1, 1978, p. 54-61.

Research output: Contribution to journalArticle

Bondy, SC, Bonnet, KC, Harrington, ME, Neurath, CZ, Nidess, R, Vernadakis, A, Vulliet, PR & York, C 1978, 'Biochemical maturation of the non-innervated chick optic lobe', Developmental Neuroscience, vol. 1, no. 1, pp. 54-61.
Bondy SC, Bonnet KC, Harrington ME, Neurath CZ, Nidess R, Vernadakis A et al. Biochemical maturation of the non-innervated chick optic lobe. Developmental Neuroscience. 1978;1(1):54-61.
Bondy, S. C. ; Bonnet, K. C. ; Harrington, M. E. ; Neurath, C. Z. ; Nidess, R. ; Vernadakis, A. ; Vulliet, Philip R ; York, C. / Biochemical maturation of the non-innervated chick optic lobe. In: Developmental Neuroscience. 1978 ; Vol. 1, No. 1. pp. 54-61.
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