Soluble epoxide hydrolase (sEH) was shown to catalyze hydrolysis of epoxides using the ionic liquids (ILs) [bmim][PF6], [bmim][N(Tf) 2], and [bmim][BF4] (where bmim=1-butyl-3- methylimidazolium, PF6=hexafluorophosphate, N(Tf)2= bis(trifluoromethylsulfonyl)imide, and BF4=tetrafluoroborate) as reaction medium. Reaction rates were generally comparable with those observed in buffer solution, and when the cress enzyme was used the hydrolysis of trans-β-methylstyrene oxide gave, through a stereoconvergent process, the corresponding optically active (1S,2R)-erythro-1-phenylpropane-1,2-diol.
- Ionic liquids
- Stereoconvergent hydrolysis
ASJC Scopus subject areas
- Process Chemistry and Technology