Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy

G. E. Swan, Charles DeCarli, B. L. Miller, T. Reed, P. A. Wolf, D. Carmelli

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

Objective: To characterize the risk factors and neuropsychological performance of two subgroups of community-dwelling, white elderly men free of severe cognitive impairment (n = 383; mean age, 72.9 ± 3.0 years) who differ on volumetric measurements of total brain parenchyma and white matter hyperintensity (WMH) volumes. Methods: Group comparisons were made of cerebrovascular disease risk factors measured at the time of imaging and at three prior examinations extending over 25 years of adult life. Measures of verbal memory and speed psychomotor processing at the time of imaging and 10 years before imaging were also available. Results: Compared with those in the 'nonatrophy' group, individuals in the subgroup with 'atrophy' (defined by low total brain volume and high WMH volume) were older, reported a higher level of depressive symptomatology, experienced a steeper decline in diastolic blood pressure (DBP) and a steeper increase in pulse pressure, were less physically active, had smoked for more years, and had a higher prevalence of several cardiovascular disease indicators, including an ankle/arm systolic blood pressure ratio less than 0.9, and hypertension. After multivariate analysis, the 25-year decline in DBP, the number of years smoked, and an ankle/arm index of less than 0.9 remained significant discriminators of the two groups. Lower levels of speeded performance at the time of imaging and a steeper 10-year decline in cognitive performance on selected tests were also observed in the atrophic group. Conclusion: Community-dwelling older adults with volumetric brain measurements associated with accelerated aging are distinguishable on the basis of several health- related characteristics. These individuals also perform less well on certain tasks involving executive functioning.

Original languageEnglish (US)
Pages (from-to)2108-2114
Number of pages7
JournalNeurology
Volume54
Issue number11
StatePublished - Jun 13 2000
Externally publishedYes

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Atrophy
Blood Pressure
Brain
Independent Living
Ankle
Arm
Cerebrovascular Disorders
Cardiovascular Diseases
Multivariate Analysis
Hypertension
Health

Keywords

  • Aging
  • Atrophy
  • MRI
  • Neuropsychological function
  • White matter hyperintensities

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Swan, G. E., DeCarli, C., Miller, B. L., Reed, T., Wolf, P. A., & Carmelli, D. (2000). Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. Neurology, 54(11), 2108-2114.

Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. / Swan, G. E.; DeCarli, Charles; Miller, B. L.; Reed, T.; Wolf, P. A.; Carmelli, D.

In: Neurology, Vol. 54, No. 11, 13.06.2000, p. 2108-2114.

Research output: Contribution to journalArticle

Swan, GE, DeCarli, C, Miller, BL, Reed, T, Wolf, PA & Carmelli, D 2000, 'Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy', Neurology, vol. 54, no. 11, pp. 2108-2114.
Swan GE, DeCarli C, Miller BL, Reed T, Wolf PA, Carmelli D. Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. Neurology. 2000 Jun 13;54(11):2108-2114.
Swan, G. E. ; DeCarli, Charles ; Miller, B. L. ; Reed, T. ; Wolf, P. A. ; Carmelli, D. / Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. In: Neurology. 2000 ; Vol. 54, No. 11. pp. 2108-2114.
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