Bioavailability of urea nitrogen for the low birthweight infant

S. M. Donovan, B. Lonnerdal, S. A. Atkinson

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Previous studies have demonstrated increase retention (40%) of dietary urea nitrogen by term infants recovering from infection compared to healthy infants (13%), possibly due to a higher requirement for nitrogen. Since low birthweight infants also have a high requirement for nitrogen, the bioavailability of urea nitrogen was investigated in low birthweight infants using 15N, 15N-urea. Four low birthweight infants (gestational age = 30 ± 2.2 weeks [mean ± SD], birthweight = 1.4 ± 0.3 kg) were fed formula enriched with 15N, 15N-urea. Metabolic balance studies (72 hours) were performed with urine and fecal collections. Nitrogen was quantitated by Kjeldahl analysis and 15N, 15N-urea by gas chromatography/mass spectrometry. Mean nitrogen intake was 489 ± 32 mg/kg/d, with 75% nitrogen absorption and 62% nitrogen retention. Maximum urinary enrichment was 8%. Cumulative 15N, 15N-urea excretion was 72%, resulting in 28% retention. Thus the bioavailability of urea nitrogen for low birthweight infants appears to be intermediate between compromised and normal term infants.

Original languageEnglish (US)
Pages (from-to)899-905
Number of pages7
JournalActa Paediatrica Scandinavica
Volume79
Issue number10
StatePublished - 1990
Externally publishedYes

Fingerprint

Biological Availability
Urea
Nitrogen
Urine Specimen Collection
Gas Chromatography-Mass Spectrometry
Gestational Age
Infection

Keywords

  • Infant formula
  • Low birthweight infants
  • Nitrogen
  • Non-protein nitrogen
  • Stable isotopes
  • Urea nitrogen

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Donovan, S. M., Lonnerdal, B., & Atkinson, S. A. (1990). Bioavailability of urea nitrogen for the low birthweight infant. Acta Paediatrica Scandinavica, 79(10), 899-905.

Bioavailability of urea nitrogen for the low birthweight infant. / Donovan, S. M.; Lonnerdal, B.; Atkinson, S. A.

In: Acta Paediatrica Scandinavica, Vol. 79, No. 10, 1990, p. 899-905.

Research output: Contribution to journalArticle

Donovan, SM, Lonnerdal, B & Atkinson, SA 1990, 'Bioavailability of urea nitrogen for the low birthweight infant', Acta Paediatrica Scandinavica, vol. 79, no. 10, pp. 899-905.
Donovan SM, Lonnerdal B, Atkinson SA. Bioavailability of urea nitrogen for the low birthweight infant. Acta Paediatrica Scandinavica. 1990;79(10):899-905.
Donovan, S. M. ; Lonnerdal, B. ; Atkinson, S. A. / Bioavailability of urea nitrogen for the low birthweight infant. In: Acta Paediatrica Scandinavica. 1990 ; Vol. 79, No. 10. pp. 899-905.
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